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[Effects of ingestion of oxidized fish oils on membrane fluidity, and the activity of hepatic microsome enzymes in rats. Influence of vitamin A overload].

作者信息

Mounié J, Faye B, Champion L, Goudonnet H, Magdalou J, Escousse A, Truchot R C

出版信息

C R Seances Soc Biol Fil. 1986;180(4):416-25.

PMID:2948621
Abstract

Oxidized fish oil (OFO) feeding is followed in the rat by the increase of vitamin A plasmatic level, and modifications of microsomal membranes (decrease of fluorophore ANS fixation). This inhibit the microsomal increase of cytochrome P 450, mixed function oxidase (MFO), any UDP-glucuronosyl transferases (group I) induced by phenobarbital treatment. On the other hand, vit A over load modify the microsomal structure of the opposite way (increase of ANS fixation). This effect is enlarged when OFO is added. In this case cyt P 450 is decreased. It seems that the magnification of vit. A effect is similar to increased microsomal membrane lability by oxidized fish oil addition.

摘要

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