Yoo Taeyoung, Choi Wonsuk, Hong Jin-Hee, Lee Ju-Yeon, Kim Jae-Min, Shin Il-Seon, Yang Soo Jin, Amminger Paul, Berk Michael, Yoon Jin-Sang, Kim Sung-Wan
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Psychiatry Investig. 2018 Apr;15(4):396-401. doi: 10.30773/pi.2017.08.30. Epub 2018 Feb 28.
This study examined the association between vitamin D and metabolic syndrome in patients with psychotic disorders.
The study enrolled 302 community-dwelling patients with psychotic disorders. Sociodemographic and clinical characteristics, including blood pressure, physical activity, and dietary habit were gathered. Laboratory examinations included vitamin D, lipid profile, fasting plasma glucose, HbA1c, liver function, and renal function. Vitamin D insufficiency was defined as <20 ng/mL. Clinical characteristics associated with vitamin D insufficiency were identified.
Among the 302 participants, 236 patients (78.1%) had a vitamin D insufficiency and 97 (32.1%) had metabolic syndrome. Vitamin D insufficiency was significantly associated with the presence of metabolic syndrome (p=0.006) and hypertension (p=0.017). Significant increases in triglycerides and alanine transaminase were observed in the group with a vitamin D insufficiency (p=0.002 and 0.011, respectively). After adjusting for physical activity and dietary habit scores, vitamin D insufficiency remained significantly associated with metabolic syndrome and hypertension.
Vitamin D insufficiency was associated with metabolic syndrome and was particularly associated with high blood pressure, although the nature, direction and implications of this association are unclear.
本研究探讨了精神病患者维生素D与代谢综合征之间的关联。
该研究纳入了302名社区居住的精神病患者。收集了社会人口学和临床特征，包括血压、身体活动和饮食习惯。实验室检查包括维生素D、血脂谱、空腹血糖、糖化血红蛋白、肝功能和肾功能。维生素D不足定义为<20 ng/mL。确定与维生素D不足相关的临床特征。
在302名参与者中，236名患者（78.1%）存在维生素D不足，97名（32.1%）患有代谢综合征。维生素D不足与代谢综合征的存在（p=0.006）和高血压（p=0.017）显著相关。维生素D不足组的甘油三酯和丙氨酸转氨酶显著升高（分别为p=0.002和0.011）。在调整身体活动和饮食习惯得分后，维生素D不足仍与代谢综合征和高血压显著相关。
维生素D不足与代谢综合征相关，尤其与高血压相关，尽管这种关联的性质、方向和意义尚不清楚。
