Bojar Iwona, Raczkiewicz Dorota, Sarecka-Hujar Beata
Department of Women's Health, Institute of Rural Health, 20-950 Lublin, Poland.
Institute of Statistics and Demography, Collegium of Economic Analysis, SGH Warsaw School of Economics, 02-554 Warsaw, Poland.
Medicina (Kaunas). 2020 Sep 30;56(10):511. doi: 10.3390/medicina56100511.
Depression is a serious problem affecting people worldwide, however it more commonly concerns women. Depression reduces the quality of life and, in many cases, leads to suicide. Numerous new biological factors have been demonstrated to have an impact on the pathogenesis of depression, including vitamin D, thyroid hormones, as well as factors related to heart disease. The aim of the study was to assess the impact of serum thyroid stimulating hormone (TSH) and vitamin D concentrations as well as metabolic syndrome on the severity of depression in Polish postmenopausal women from urban and rural areas. The study was conducted in 2018-2019 in the Lublin region, Poland, and comprised 396 postmenopausal women (239 living in rural areas and 157 living in urban areas). Metabolic syndrome criteria according to the International Diabetes Federation and Beck Depression Inventory were used, and laboratory blood tests were performed. A significantly higher percentage of the examined rural residents had moderate or severe depression in comparison to the urban ones ( = 0.049). The examined women from rural areas had a significantly higher serum vitamin D concentration in comparison to the urban ones ( < 0.001). The rural residents more commonly had below-normal levels of serum TSH and less commonly had normal levels in comparison to the urban residents. Metabolic syndrome was found in 70% of the rural residents, and that number was significantly lower in the urban ones (22%, < 0.001). The severity of depression in postmenopausal Polish women was correlated negatively with the serum TSH concentration in women from rural areas. The severity of depression was increased in urban postmenopausal women with hypertension. No correlation of the depression severity with the serum vitamin D concentration or other criteria of metabolic syndrome was found.
抑郁症是一个影响全球人群的严重问题，不过它在女性中更为常见。抑郁症会降低生活质量，在许多情况下还会导致自杀。大量新的生物学因素已被证明对抑郁症的发病机制有影响，包括维生素D、甲状腺激素以及与心脏病相关的因素。本研究的目的是评估血清促甲状腺激素（TSH）和维生素D浓度以及代谢综合征对波兰城乡绝经后女性抑郁症严重程度的影响。该研究于2018年至2019年在波兰卢布林地区进行，共纳入396名绝经后女性（239名居住在农村地区，157名居住在城市地区）。采用了国际糖尿病联盟的代谢综合征标准和贝克抑郁量表，并进行了实验室血液检测。与城市居民相比，接受检查的农村居民中患有中度或重度抑郁症的比例显著更高（ = 0.049）。与城市居民相比，来自农村地区的受检女性血清维生素D浓度显著更高（ < 0.001）。与城市居民相比，农村居民血清TSH水平低于正常的情况更为常见，而处于正常水平的情况则较少见。70%的农村居民存在代谢综合征，这一比例在城市居民中显著更低（22%， < 0.001）。波兰绝经后女性的抑郁症严重程度与农村女性的血清TSH浓度呈负相关。患有高血压的城市绝经后女性抑郁症严重程度增加。未发现抑郁症严重程度与血清维生素D浓度或其他代谢综合征标准之间存在相关性。
