卡塔尔人群中维生素D缺乏症的患病率及其与代谢综合征的关联。
Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population.
作者信息
Al-Dabhani K, Tsilidis K K, Murphy N, Ward H A, Elliott P, Riboli E, Gunter M, Tzoulaki I
机构信息
Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
出版信息
Nutr Diabetes. 2017 Apr 10;7(4):e263. doi: 10.1038/nutd.2017.14.
OBJECTIVES
Despite long hours of sunlight in Qatar and other regions of the Middle East, vitamin D deficiency has been rising. In parallel, the prevalence of metabolic syndrome has also been increasing in Qatar. Vitamin D levels have been associated with metabolic syndrome but the data are inconsistent and no studies have addressed these inter-relationships in a Middle Eastern population where the prevalence of these conditions is high. The objective is to investigate the prevalence of vitamin D deficiency and its association with metabolic syndrome and its components in the Qatar Biobank population.
METHODS
A cross-sectional study of 1205 participants (702 women and 503 men) from the Qatar Biobank, comprising Qataris and non-Qataris between the ages of 18 and 80 years, was used to perform multivariate linear regression analyses to examine the association between metabolic syndrome and prevalence of vitamin D deficiency (defined as <20 ng ml serum vitamin D levels) adjusting for age, sex, ethnicity, season of blood collection, physical activity and education. Odds ratios and 95% confidence intervals were calculated for all analyses.
RESULTS
Approximately 64% of participants were vitamin D deficient (<20 ng ml) with more men being deficient (68.6%) than women (61.3%). Serum vitamin D was 8% lower in individuals with metabolic syndrome (RR: 0.92, 95%CI: 0.87-0.98, P-value: 0.01) compared to individuals without metabolic syndrome. Waist circumference and HDL as well as high triglyceride levels were also significantly positively associated with vitamin D deficiency. No association was found between the other components of metabolic syndrome or diabetes and the presence of vitamin D deficiency.
CONCLUSIONS
Vitamin D deficiency is prevalent in this Qatari population. Presence of metabolic syndrome was associated with presence of vitamin D deficiency. Future prospective studies need to be conducted to investigate the potential for causality.
目的
尽管卡塔尔及中东其他地区日照时间长，但维生素D缺乏情况却在不断增加。与此同时，卡塔尔代谢综合征的患病率也在上升。维生素D水平与代谢综合征有关，但数据并不一致，且尚无研究探讨中东地区这些疾病患病率较高人群中的这些相互关系。目的是调查卡塔尔生物样本库人群中维生素D缺乏的患病率及其与代谢综合征及其组成成分的关联。
方法
对卡塔尔生物样本库的1205名参与者（702名女性和503名男性）进行横断面研究，这些参与者年龄在18至80岁之间，包括卡塔尔人和非卡塔尔人，采用多元线性回归分析来检验代谢综合征与维生素D缺乏患病率（定义为血清维生素D水平<20 ng/ml）之间的关联，并对年龄、性别、种族、采血季节、身体活动和教育程度进行校正。所有分析均计算比值比和95%置信区间。
结果
约64%的参与者维生素D缺乏（<20 ng/ml），男性缺乏率（68.6%）高于女性（61.3%）。与无代谢综合征的个体相比，代谢综合征个体的血清维生素D低8%（RR：0.92，95%CI：0.87-0.98，P值：0.01）。腰围、高密度脂蛋白以及高甘油三酯水平也与维生素D缺乏显著正相关。未发现代谢综合征的其他组成成分或糖尿病与维生素D缺乏之间存在关联。
结论
维生素D缺乏在卡塔尔人群中普遍存在。代谢综合征的存在与维生素D缺乏的存在有关。未来需要进行前瞻性研究以调查因果关系的可能性。
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