Mansouri Masoume, Abasi Roshanak, Nasiri Morteza, Sharifi Farshad, Vesaly Sedyghe, Sadeghi Omid, Rahimi Nayere, Sharif Nasrin Akbary
Student Health Services, Health Center of Tarbiat Modares University, Tehran, Iran.
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Diabetes Metab Syndr. 2018 May;12(3):393-398. doi: 10.1016/j.dsx.2018.01.007. Epub 2018 Jan 31.
We aimed to assess the association of vitamin D status with metabolic syndrome and its components among high educated Iranian adults.
In this cross-sectional study, 352 faculty members with age of 35 years or more, belong to Tarbiat Modares University, Tehran, Islamic Republic of Iran, were recruited during 2016 and 2017. Fasting blood samples were obtained to quantify serum 25(OH)D concentrations, glycemic indicators and lipid profile. Metabolic syndrome was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III). Multivariate logistic regression adjusted for potential confounders was used to evaluate the association between vitamin D status and metabolic syndrome.
Metabolic syndrome and vitamin D insufficiency were prevalent among 26% and 60.2% of subjects, respectively. There was no statistically significant difference in the prevalence of metabolic syndrome across quartiles of 25(OH)D levels either before or after adjusting for potential confounders (OR: 0.94, 95% CI: 0.43-1.95). In terms of metabolic syndrome components, subjects in the highest quartile of vitamin D levels had 59% decreased risk of abdominal obesity compared with those in the lowest quartile (OR: 0.41, 95% CI: 0.17-0.99), after adjusting for potential confounders. Such inverse relationship was also seen for elevated blood pressure (OR: 0.37, 95% CI: 0.14-0.99), and abnormal glucose homeostasis (OR: 0.40, 95% CI: 0.19-0.85).
Serum levels of 25(OH)D was inversely associated with the risk of abdominal obesity, hypertension, and abnormal glucose homeostasis. However, no significant relationship was seen for metabolic syndrome.
我们旨在评估伊朗高学历成年人中维生素D状态与代谢综合征及其组分之间的关联。
在这项横断面研究中，2016年至2017年期间招募了352名年龄在35岁及以上、隶属于伊朗伊斯兰共和国德黑兰的莫达雷斯大学的教职员工。采集空腹血样以测定血清25(OH)D浓度、血糖指标和血脂谱。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告（ATP III）的指南进行定义。采用多因素逻辑回归分析，并对潜在混杂因素进行校正，以评估维生素D状态与代谢综合征之间的关联。
代谢综合征和维生素D不足在分别在26%和60.2%的研究对象中普遍存在。在校正潜在混杂因素之前或之后，25(OH)D水平四分位数间代谢综合征的患病率均无统计学显著差异（比值比：0.94，95%置信区间：0.43 - 1.95）。在代谢综合征组分方面，校正潜在混杂因素后，维生素D水平最高四分位数的研究对象相比最低四分位数的研究对象腹部肥胖风险降低59%（比值比：0.41，95%置信区间：0.17 - 0.99）。血压升高（比值比：0.37，95%置信区间：0.14 - 0.99）和糖代谢异常（比值比：0.40，95%置信区间：0.19 - 0.85）方面也观察到这种负相关关系。
血清25(OH)D水平与腹部肥胖、高血压和糖代谢异常风险呈负相关。然而，未观察到与代谢综合征之间存在显著关系。
