Shen Guohua, Liang Meng, Su Minggang, Kuang Anren
1 Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China.
2 Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, PR China.
Acta Radiol. 2018 Dec;59(12):1487-1493. doi: 10.1177/0284185118762245. Epub 2018 Feb 27.
18F-fluorodeoxyglucose *Equal contributors. positron emission tomography/computed tomography (18F-FDG PET/CT) has proven to be a valuable imaging modality for the assessment of bone marrow condition.
To investigate the physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging, and correlate the appearance with clinical factors including gender, body mass index, and age.
A total of 64 healthy individuals underwent PET/CT scan, and for each vertebral body, the mean and maximum standardized uptake value (SUVmean and SUVmax) were determined in the central slice of vertebral body on the transversal fused PET/CT image. For each individual, the FDG uptake of the four regions was obtained by averaging the SUVmean and SUVmax of the vertebrae in individual regions.
The FDG uptake from thoracic to sacral vertebrae showed an upward trend first, then a downward trend, while that of cervical vertebrae was relatively stable. The SUVmax and SUVmean values of bone marrow in the old group (age ≥ 50 years) were significantly lower than those in the young group (age < 50 years) in all regions of the spine ( P < 0.05). FDG uptake of the whole spine showed significant negative correlation with age, and the strongest correlation was observed in lumbar spine (SUVmean: r = -0.364, P < 0.05; SUVmax: r = -0.344, P < 0.05).
FDG uptake showed a tendency to increase first then decrease from thoracic to sacral vertebrae while the tendency was not obvious in cervical vertebrae. In addition, the glycolytic metabolism of all the four regions decreased with advancing age.
18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）已被证明是评估骨髓状况的一种有价值的成像方式。
探讨健康成年人在PET/CT成像中18F-FDG在椎体骨髓中的生理性摄取情况，并将其表现与包括性别、体重指数和年龄在内的临床因素相关联。
共64名健康个体接受了PET/CT扫描，对于每个椎体，在横向融合的PET/CT图像上椎体的中央层面确定平均和最大标准化摄取值（SUVmean和SUVmax）。对于每个个体，通过平均各个区域椎体的SUVmean和SUVmax来获得四个区域的FDG摄取量。
从胸椎到骶椎的FDG摄取呈先上升后下降趋势，而颈椎的FDG摄取相对稳定。在脊柱的所有区域，老年组（年龄≥50岁）骨髓的SUVmax和SUVmean值均显著低于青年组（年龄<50岁）（P<0.05）。全脊柱的FDG摄取与年龄呈显著负相关，在腰椎观察到的相关性最强（SUVmean：r = -0.364，P<0.05；SUVmax：r = -0.344，P<0.05）。
从胸椎到骶椎，FDG摄取呈先增加后减少趋势，而颈椎这种趋势不明显。此外，所有四个区域的糖酵解代谢均随年龄增长而降低。
