van Vliet Kirsten E, van Eck-Smit Berthe L F, de Jong Vincent M, Goslings J Carel, Schep Niels W L, Termaat M Frank
aSchool of Medicine, University of Amsterdam Departments of bNuclear Medicine cSurgery, Trauma Unit, AMC, Amsterdam dDepartment of Surgery, Trauma Unit, Maasstad Ziekenhuis, Rotterdam eDepartment of Surgery, Trauma Unit, LUMC, Leiden, The Netherlands.
Nucl Med Commun. 2016 Jun;37(6):589-92. doi: 10.1097/MNM.0000000000000483.
Fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) has proven to be a valuable imaging modality with high diagnostic accuracy for the detection of bone infections. However, the physiological uptake values for F-FDG in the long bones of the lower extremity have not been established yet. This hampers correct interpretation of a F-FDG-PET/CT scan.
The purpose of this study was to determine the physiological uptake values of F-FDG in the long bones of the lower extremities, including the femur and the tibia.
We retrospectively analyzed the F-FDG-PET/CT scan of 84 consecutive patients from our database. F-FDG uptake parameters included mean standardized uptake value (SUVmean) and maximum standardized uptake value (SUVmax). Both SUVs were determined in the diaphyseal region of the femur and the tibia.
SUVmean for the femoral diaphysis was 0.46 [95% confidence interval (CI) 0.42-0.49] and SUVmax was 0.81 (95% CI 0.74-0.88). For the tibial diaphysis, SUVmean was 0.34 (95% CI 0.32-0.37) and SUVmax was 0.61 (95% CI 0.56-0.65). SUVmean and SUVmax of the femur were significantly higher than that of the tibia (both P<0.01). SUVs for men were not significantly different from that for women and did not discriminate between age classes.
For a correct interpretation of the F-FDG-PET/CT scan, we have determined the F-FDG uptake values in the long bones of the femur and the tibia. A SUVmean less than 0.5 and a SUVmax less than 0.8 can be considered as normal bone, irrespective of sex or age.
氟-18氟脱氧葡萄糖（F-FDG）正电子发射断层显像/计算机断层扫描（PET/CT）已被证明是一种对骨感染具有高诊断准确性的有价值的成像方式。然而，下肢长骨中F-FDG的生理性摄取值尚未确定。这妨碍了对F-FDG-PET/CT扫描的正确解读。
本研究的目的是确定F-FDG在下肢长骨（包括股骨和胫骨）中的生理性摄取值。
我们回顾性分析了数据库中84例连续患者的F-FDG-PET/CT扫描。F-FDG摄取参数包括平均标准化摄取值（SUVmean）和最大标准化摄取值（SUVmax）。两种SUV值均在股骨和胫骨的骨干区域测定。
股骨干的SUVmean为0.46[95%置信区间（CI）0.42-0.49]，SUVmax为0.81（95%CI 0.74-0.88）。胫骨干的SUVmean为0.34（95%CI 0.32-0.37），SUVmax为0.61（95%CI 0.56-0.65）。股骨的SUVmean和SUVmax显著高于胫骨（均P<0.01）。男性的SUV值与女性无显著差异，且在各年龄组之间无差异。
为了正确解读F-FDG-PET/CT扫描，我们已确定了股骨和胫骨长骨中的F-FDG摄取值。无论性别或年龄，SUVmean小于0.5且SUVmax小于0.8可被视为正常骨骼。
