Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Center for Primary Health Care Research, Lund University, Skåne University Hospital, Malmö, Sweden.
Nutr J. 2018 Feb 27;17(1):34. doi: 10.1186/s12937-018-0335-0.
Consumption of polyphenol-rich fruits and vegetables may improve postprandial glucose and insulin levels and hence promote well-being. Previously it has been observed that consumption of bilberry decreases the postprandial insulin demand. The intention with the present study was to compare the impact of different supplements with various polyphenol profiles, on the postprandial glucose and insulin responses in healthy young adults.
In a randomized, controlled, crossover study the postprandial glycemic and insulin responses were observed in eleven healthy adults after intake of five different beverages containing bilberry (European blueberry), blackcurrant, beetroot, mango and rose hip, respectively; all drinks were enriched with the same composition of fermented oatmeal and probiotics. The control was a glucose drink. The profile and content of the polyphenols in the different beverages were determined by HPLC-DAD analysis. The antioxidative capacity of the different beverages were measured by TEAC and DPPH assays.
Beverages containing bilberry, blackcurrant, mango or rose hip significantly attenuated the early postprandial insulin response (0-90 min), but showed no effect on glucose response. Drinks with bilberry or rose hip reduced the insulin response from the very early phase (0-30 min), and had significantly lower insulin index compared with the control. The efficiency of the bilberry and rose hip to decrease early postprandial insulin responses correlated with higher phenolic contents.
Supplements with bilberry, blackcurrant, mango or rose hip in the tested probiotic and oatmeal enriched beverage attenuated early-phase insulin response, but had no effect on the postprandial glycemic response. The improved ability of bilberry and rose hip to lower the very early phase of insulin response seems to be due to a higher phenolic content.
The study was retrospectively registered at ClinicalTrials.gov with number NCT03159065 .
食用富含多酚的水果和蔬菜可能改善餐后血糖和胰岛素水平，从而促进健康。此前已经观察到，食用越橘可降低餐后胰岛素需求。本研究旨在比较具有不同多酚特征的不同补充剂对健康年轻成年人餐后血糖和胰岛素反应的影响。
在一项随机、对照、交叉研究中，11 名健康成年人分别饮用含有越橘（欧洲蓝莓）、黑加仑、甜菜根、芒果和玫瑰果的五种不同饮料后，观察餐后血糖和胰岛素反应；所有饮料均富含相同组成的发酵燕麦片和益生菌。对照为葡萄糖饮料。通过 HPLC-DAD 分析确定不同饮料中多酚的特征和含量。通过 TEAC 和 DPPH 测定法测量不同饮料的抗氧化能力。
含有越橘、黑加仑、芒果或玫瑰果的饮料显著减弱了早期餐后胰岛素反应（0-90 分钟），但对血糖反应没有影响。含越橘或玫瑰果的饮料从早期（0-30 分钟）开始降低胰岛素反应，与对照相比，胰岛素指数显著降低。越橘和玫瑰果降低早期餐后胰岛素反应的效率与较高的酚类含量相关。
在测试的益生菌和燕麦片强化饮料中，含有越橘、黑加仑、芒果或玫瑰果的补充剂可减弱早期胰岛素反应，但对餐后血糖反应没有影响。越橘和玫瑰果降低早期胰岛素反应的能力提高似乎是由于酚类含量较高。
该研究在 ClinicalTrials.gov 上进行了回顾性注册，编号为 NCT03159065。
