血管生成——拉曼成像在乳腺癌生长、进展和扩散中的关键步骤。

Angiogenesis - a crucial step in breast cancer growth, progression and dissemination by Raman imaging.

机构信息

Lodz University of Technology, Faculty of Chemistry, Institute of Applied Radiation Chemistry, Laboratory of Laser Molecular Spectroscopy, Wroblewskiego 15, 93-590 Lodz, Poland.

Lodz University of Technology, Faculty of Chemistry, Institute of Applied Radiation Chemistry, Laboratory of Laser Molecular Spectroscopy, Wroblewskiego 15, 93-590 Lodz, Poland..

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:338-345. doi: 10.1016/j.saa.2018.02.058. Epub 2018 Mar 2.

DOI:10.1016/j.saa.2018.02.058

PMID:29486925

Abstract

Combined micro-Raman imaging and AFM imaging are efficient methods for analyzing human tissue due to their high spatial and spectral resolution as well as sensitivity to subtle chemical, structural and topographical changes. The aim of this study was to determine biochemical composition and mechanical topography around blood vessels in the tumor mass of human breast tissue. Significant alterations of the chemical composition and structural architecture around the blood vessel were found compared to the normal breast tissue. A pronounced increase of collagen-fibroblast-glycocalyx network, as well as enhanced lactic acid, and glycogen activity in patients affected by breast cancer were reported.

摘要

联合微拉曼成像和原子力显微镜成像由于具有高空间和光谱分辨率以及对细微化学、结构和形貌变化的敏感性，是分析人体组织的有效方法。本研究旨在确定人类乳腺组织肿瘤中血管周围的生化组成和力学形貌。与正常乳腺组织相比，发现血管周围的化学成分和结构形态有明显改变。报告称，乳腺癌患者的胶原纤维母细胞糖萼网络明显增加，以及乳酸和糖原活性增强。