Department of Gynecology, The Fourth Affiliated Hospital of Xinjiang Medical University, No. 116 Huanghe Road, Urumqi, 214000, Xinjiang, China.
BMC Womens Health. 2021 Mar 11;21(1):104. doi: 10.1186/s12905-021-01198-4.
It's necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS).
Newly diagnosed PCOS patients treated in our hospital were selected, and healthy women who took physical examination during the same period as healthy controls. We detected and compared the related serum indicators between two groups, Pearson correlation were conducted to identify the factors associated with β-trophin and ES, and the influencing factors of β-trophin and ES were analyzed by logistic regression.
A total of 62 PCOS patients and 65 healthy controls were included. The BMI, WHI, LH, FSH, TT, FAI, FBG, FINS, HOMA-IR, TC, TG, LDL, ES in PCOS patients were significantly higher than that of healthy controls, while the SHBG and HDL in PCOS patients were significantly lower than that of healthy controls (all p < 0.05). β-trophin was closely associated with BMI (r = 0.427), WHR (r = 0.504), FBG (r = 0.385), TG (r = 0.405) and LDL (r = 0.302, all p < 0.05), and ES was closely associated with BMI (r = 0.358), WHR (r = 0.421), FBG (r = 0.343), TC (r = 0.319), TG (r = 0.404, all p < 0.05). TG, BMI, WHR and FBG were the main factors affecting the serum β-trophin levels (all p < 0.05). FBG, TC and BMI were the main factors affecting the serum ES levels (all p < 0.05). The TG, β-trophin, ES level in PCOS patients with insulin resistance (IR) were significantly higher than that of those without IR (all p < 0.05).
Increased β-trophin is closely associated with increased ES in patients with PCOS, which may be the useful indicators for the management of PCOS.
研究多囊卵巢综合征（PCOS）患者血清β-人绒毛膜促性腺激素（β-trophin）和内皮抑素（ES）水平及其影响因素非常必要。
选取我院收治的新诊断为 PCOS 的患者作为观察组，同时选取同期健康体检的健康女性作为健康对照组。检测并比较两组的相关血清指标，采用 Pearson 相关性分析来确定与β-trophin 和 ES 相关的因素，采用 logistic 回归分析β-trophin 和 ES 的影响因素。
共纳入 62 例 PCOS 患者和 65 例健康对照者。PCOS 患者的 BMI、WHI、LH、FSH、TT、FAI、FBG、FINS、HOMA-IR、TC、TG、LDL、ES 明显高于健康对照组，而 PCOS 患者的 SHBG 和 HDL 明显低于健康对照组（均 P<0.05）。β-trophin 与 BMI（r=0.427）、WHR（r=0.504）、FBG（r=0.385）、TG（r=0.405）和 LDL（r=0.302，均 P<0.05）密切相关，ES 与 BMI（r=0.358）、WHR（r=0.421）、FBG（r=0.343）、TC（r=0.319）、TG（r=0.404，均 P<0.05）密切相关。TG、BMI、WHR 和 FBG 是影响血清β-trophin 水平的主要因素（均 P<0.05）。FBG、TC 和 BMI 是影响血清 ES 水平的主要因素（均 P<0.05）。胰岛素抵抗（IR）患者的 PCOS 患者的 TG、β-trophin、ES 水平明显高于无 IR 患者（均 P<0.05）。
PCOS 患者中β-trophin 水平升高与 ES 水平升高密切相关，这可能是 PCOS 管理的有用指标。
