Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Incheon St. Mary's hospital, Incheon, 21431, Korea.
Sci Rep. 2018 Feb 27;8(1):3735. doi: 10.1038/s41598-018-21550-3.
Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using 51,405 non-diabetic subjects. Individuals who developed type 2 diabetes were more likely to be older and male, to have high body mass index (BMI), blood pressure, fasting blood glucose, and total cholesterol, to be current smokers and frequent drinkers, to be hypertensive and hyperlipidemic, and to have a family history of diabetes, compared to those without type 2 diabetes. Compared with the consistently non-obese group, there was a higher hazard ratio for incident diabetes (95% confidence interval) in subjects becoming obese [1.49 (1.26-1.77)] and remaining obese [2.56 (2.34-2.81)] after adjustment for confounding factors. Decreased BMI was significantly associated with lower risks for incident diabetes and the trends were more evident in the non-obese group. However, overall there was no significant association of increased BMI with incident diabetes. In conclusion, weight loss was significantly associated with lower risk for diabetes both in non-obese and obese Koreans, but particularly in the non-obese.
肥胖是 2 型糖尿病的一个已知危险因素，但关于体重变化与非肥胖人群糖尿病风险之间的关系的数据很少。本研究旨在调查体重变化对韩国 2 型糖尿病发病率的影响，共纳入了 51405 名非糖尿病患者。与无 2 型糖尿病者相比，发生 2 型糖尿病的个体更可能是年龄较大和男性，具有更高的体重指数（BMI）、血压、空腹血糖和总胆固醇，更可能是当前吸烟者和经常饮酒者，患有高血压和高血脂，并且有糖尿病家族史。与一直保持非肥胖状态的个体相比，在调整混杂因素后，体重增加（肥胖）[1.49（1.26-1.77）]和持续肥胖的个体发生糖尿病的风险比更高[2.56（2.34-2.81）]。BMI 降低与发生糖尿病的风险降低显著相关，这种趋势在非肥胖组中更为明显。然而，总体而言，BMI 增加与发生糖尿病之间没有显著关联。综上所述，体重减轻与韩国非肥胖和肥胖人群发生糖尿病的风险降低显著相关，但在非肥胖人群中更为明显。
