Graduate School, Beijing University of Chinese Medicine, Beijng, (100029), China.
The Third Affiliate Hospital of Beijing University of Chinese Medicine, Beijing, (100029), China.
Sci Rep. 2018 Feb 27;8(1):3724. doi: 10.1038/s41598-018-21789-w.
Ischemic myocardium initiates the mobilization and homing of bone marrow mesenchymal stem cells (BM-MSCs) to promote myocardial regeneration after acute myocardial infarction (AMI). Inflammation caused by necrotic cardiomyocytes induce major pathological changes (cardiac remodeling and myocardial apoptosis) as well as anxiety disorder. This process may be inhibited by the differentiation and paracrine effects of BM-MSCs. However, the spontaneous mobilization of BMSCs is insufficient to prevent this effect. Given the anti-inflammatory effects of BM-MSCs, ventricular remodeling and anxiety following AMI, methods focused on enhancing BMSCs mobilization are promising. BFG is a classical traditional Chinese prescription medicine and has been proved effective in treating AMI and reducing anxiety, but the potential mechanism of its function remains unknown. In the present study, we explored the effects of Chaihulonggumulitang (BFG) on AMI and anxiety in vivo and in vitro. We also tested its effects in promoting BMSCs mobilization and alleviating inflammation. Our data showed that the classical Chinese prescription BFG promoted BM-MSCs mobilization, inhibited inflammatory response, and improved heart damage and anxiety developed from AMI. Thus, we provided an underlying mechanism of BFG function in psycho-cardiology conditions such as AMI.
缺血性心肌引发骨髓间充质干细胞（BM-MSCs）的动员和归巢，以促进急性心肌梗死（AMI）后的心肌再生。坏死心肌细胞引起的炎症会导致主要的病理变化（心脏重构和心肌细胞凋亡）以及焦虑障碍。这种过程可能会被 BM-MSCs 的分化和旁分泌作用所抑制。然而，BM-MSCs 的自发动员不足以预防这种作用。鉴于 BM-MSCs 的抗炎作用，AMI 后心室重构和焦虑，可以通过关注增强 BMSCs 动员的方法来治疗。白虎加人参汤（BFG）是一种经典的中药方剂，已被证明可有效治疗 AMI 和减轻焦虑，但它的功能的潜在机制仍不清楚。在本研究中，我们探讨了白虎加人参汤在体内和体外对 AMI 和焦虑的影响。我们还测试了它促进 BMSCs 动员和减轻炎症的作用。我们的数据表明，经典的中药方剂白虎加人参汤促进了 BM-MSCs 的动员，抑制了炎症反应，并改善了由 AMI 引起的心脏损伤和焦虑。因此，我们为白虎加人参汤在心理心脏病学领域（如 AMI）的功能提供了一个潜在的机制。
