QseC Mediates Osmotic Stress Resistance and Biofilm Formation in .

is known as a commensal organism discovered in the upper respiratory tract of swine where the pathogenic bacteria survive in various adverse environmental stress. QseC, a histidine protein kinase of the two-component regulatory systems CheY/QseC, is involved in the environmental adaptation in bacteria. To investigate the role of QseC in coping with the adverse environment stresses and survive in the host, we constructed a mutant of serovar 13 strain (Δ), MY1902. In this study, we found that QseC was involved in stress tolerance of , by the Δ exhibited a decreased resistance to osmotic pressure, oxidative stress, and heat shock. Moreover, the Δ weakened the ability to take up iron and biofilm formation. We also found that the QseC participate in sensing the epinephrine in environment to regulate the density of .