He Lvqin, Dai Ke, Wen Xintian, Ding Lingqiang, Cao Sanjie, Huang Xiaobo, Wu Rui, Zhao Qin, Huang Yong, Yan Qigui, Ma Xiaoping, Han Xinfeng, Wen Yiping
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Sichuan Science-observation Experimental Station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, China.
Front Microbiol. 2018 Feb 13;9:212. doi: 10.3389/fmicb.2018.00212. eCollection 2018.
is known as a commensal organism discovered in the upper respiratory tract of swine where the pathogenic bacteria survive in various adverse environmental stress. QseC, a histidine protein kinase of the two-component regulatory systems CheY/QseC, is involved in the environmental adaptation in bacteria. To investigate the role of QseC in coping with the adverse environment stresses and survive in the host, we constructed a mutant of serovar 13 strain (Δ), MY1902. In this study, we found that QseC was involved in stress tolerance of , by the Δ exhibited a decreased resistance to osmotic pressure, oxidative stress, and heat shock. Moreover, the Δ weakened the ability to take up iron and biofilm formation. We also found that the QseC participate in sensing the epinephrine in environment to regulate the density of .
被认为是一种在猪的上呼吸道中发现的共生生物，致病细菌在各种不利的环境压力下在其中存活。QseC是双组分调节系统CheY/QseC中的一种组氨酸蛋白激酶，参与细菌的环境适应。为了研究QseC在应对不利环境压力和在宿主体内存活中的作用，我们构建了血清型13菌株（Δ）MY1902的突变体。在本研究中，我们发现QseC参与了的应激耐受性，因为Δ对渗透压、氧化应激和热休克的抗性降低。此外，Δ削弱了摄取铁和生物膜形成的能力。我们还发现QseC参与感知环境中的肾上腺素以调节的密度。
