细胞静止：转化生长因子β如何保护癌细胞免受化疗影响。
Cellular quiescence: How TGFβ protects cancer cells from chemotherapy.
作者信息
Brown Jessie A, Schober Markus
机构信息
The Ronald O. Perelman Department of Dermatology, New York, NY, USA.
New York University School of Medicine, New York, NY, USA.
出版信息
Mol Cell Oncol. 2018 Jan 23;5(2):e1413495. doi: 10.1080/23723556.2017.1413495. eCollection 2018.
Abstract
Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFβ signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFβ/Smad signaling can't enter quiescence and subsequently die from chemotherapy.
摘要
利用一种功能性增殖报告基因，我们在完整的鳞状细胞癌中鉴定出静止的肿瘤增殖癌细胞（TPCs），并发现转化生长因子β（TGFβ）信号传导控制它们可逆地进入生长停滞状态，从而保护TPCs免受化疗影响。TGFβ/ Smad信号传导受损的TPCs无法进入静止状态，随后死于化疗。
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