代谢在细胞静止中的作用。
The role of metabolism in cellular quiescence.
机构信息
UT Southwestern Medical Center, 5323 Harry Hines Blvd, MC9040 ND13.214, Dallas, TX 75390, USA.
出版信息
J Cell Sci. 2023 Aug 15;136(16). doi: 10.1242/jcs.260787.
Abstract
Cellular quiescence is a dormant, non-dividing cell state characterized by significant shifts in physiology and metabolism. Quiescence plays essential roles in a wide variety of biological processes, ranging from microbial sporulation to human reproduction and wound repair. Moreover, when the regulation of quiescence is disrupted, it can drive cancer growth and compromise tissue regeneration after injury. In this Review, we examine the dynamic changes in metabolism that drive and support dormant and transiently quiescent cells, including spores, oocytes and adult stem cells. We begin by defining quiescent cells and discussing their roles in key biological processes. We then examine metabolic factors that influence cellular quiescence in both healthy and disease contexts, and how these could be leveraged in the treatment of cancer.
摘要
细胞静止是一种休眠的、非分裂的细胞状态，其特征是生理和代谢发生显著变化。静止在广泛的生物过程中发挥着重要作用，从微生物的孢子形成到人类的生殖和伤口修复。此外，当静止的调节被打乱时，它会促进癌症的生长，并损害损伤后的组织再生。在这篇综述中，我们研究了驱动和支持休眠和短暂静止细胞（包括孢子、卵母细胞和成年干细胞）的代谢变化。我们首先定义静止细胞，并讨论它们在关键生物过程中的作用。然后，我们研究了影响健康和疾病环境中细胞静止的代谢因素，以及如何在癌症治疗中利用这些因素。
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