Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
School of Public Health, University of California, Berkeley, CA, USA.
Curr Microbiol. 2019 Jun;76(6):738-743. doi: 10.1007/s00284-018-1443-y. Epub 2018 Feb 27.
MicroRNAs (miRNAs) are a class of non-coding RNAs with ∼22 nucleotides, which are able to regulate various biological processes, including the viral life cycle and host-pathogen interactions. Long primary transcripts (pri-miRNAs) are initially transcribed in nucleus, and subsequently processed by Dicer in cytoplasm to generate mature miRNAs. Baculoviruses consist of large, enveloped, insect-pathogenic viruses with a double-stranded circular DNA genome. Recent studies suggest that baculoviruses encode some miRNAs to manipulate expression regulation of host genes, whereas host modulate viral gene expression via miRNAs to limit viral infection. In the review, we will focus on the biogenesis and functions of miRNAs and the interactions between baculoviruses, insect, and miRNAs. It will be helpful to delve into the related mechanisms of BmNPV-encoded miRNAs that contribute to infection and pathogenesis.
MicroRNAs (miRNAs) 是一类具有约 22 个核苷酸的非编码 RNA，能够调节各种生物学过程，包括病毒生命周期和宿主-病原体相互作用。长的初级转录物（pri-miRNAs）最初在细胞核中转录，然后被细胞质中的 Dicer 加工生成成熟的 miRNAs。杆状病毒是具有双链环状 DNA 基因组的大型包膜昆虫致病病毒。最近的研究表明，杆状病毒编码一些 miRNAs 来操纵宿主基因的表达调控，而宿主通过 miRNAs 来调节病毒基因的表达，以限制病毒感染。在这篇综述中，我们将重点关注 miRNAs 的生物发生和功能，以及杆状病毒、昆虫和 miRNAs 之间的相互作用。深入研究 BmNPV 编码的 miRNAs 在感染和发病机制中的相关机制将很有帮助。
