Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Hacettepe University, Samanpazari, 06100, Ankara, Turkey.
Eur J Pediatr. 2018 May;177(5):765-773. doi: 10.1007/s00431-018-3121-2. Epub 2018 Feb 27.
Primary ciliary dyskinesia (PCD) restricts lifestyle and increases morbidity. The aim of the study was to investigate anaerobic and aerobic performance in children with PCD and their healthy counterparts. Thirty-one children with PCD and 29 age- and sex-matched healthy subjects were studied. Pulmonary function, hand grip strength (HGS), quadriceps strength (QMS), physical activity, anaerobic capacity (muscle power sprint test), and aerobic performance (modified shuttle walk test (MSWT)) were determined. Pulmonary function, HGS, QMS, mean anaerobic power (MAP), and MSWT distance in PCD were significantly lower than those of healthy subjects (p < 0.05). In PCD, the MAP was significantly correlated with age, FEV, and the mean kcal for 3 days (p < 0.05), and age was its independent predictor (p < 0.05). The MSWT distance was significantly related to gender and weight (p < 0.05), and gender was selected as its independent predictor (p < 0.05). In healthy controls, the MAP was significantly associated with age, gender, FVC, FEV, HGS, QMS, and the mean kcal for three days (p < 0.05). The MSWT distance was significantly related to weight and body mass index in healthy group (p < 0.05).
Anaerobic and aerobic performance is impaired in PCD from the early stages. Age determines anaerobic performance. Gender is the determinant of aerobic performance. Whether skeletal muscle characteristics and sex-related changes in body composition affect anaerobic and aerobic capacity in PCD children warrants further study. What is Known: • Exercise performance is determined by anaerobic and aerobic power. • Few studies have shown that PCD patients have lower aerobic performance which is associated with impaired lung function. What is New: • The present research indicated that both anaerobic and aerobic exercise capacity determined using field testing is impaired in PCD from the early stages. • Anaerobic capacity was found to be independently associated with age in PCD. Higher aerobic performance is independently associated with male gender.
研究原发性纤毛运动障碍(PCD)患儿与健康对照儿童的无氧和有氧能力。
研究了 31 名 PCD 患儿和 29 名年龄和性别匹配的健康对照者。测定了肺功能、握力(HGS)、股四头肌力量(QMS)、体力活动、无氧能力(肌肉力量冲刺试验)和有氧能力(改良穿梭步行试验(MSWT))。
PCD 患儿的肺功能、HGS、QMS、平均无氧功率(MAP)和 MSWT 距离明显低于健康对照组(p<0.05)。在 PCD 中,MAP 与年龄、FEV 和 3 天平均卡路里摄入量显著相关(p<0.05),年龄是其独立预测因子(p<0.05)。MSWT 距离与性别和体重显著相关(p<0.05),性别是其独立预测因子(p<0.05)。在健康对照组中,MAP 与年龄、性别、FVC、FEV、HGS、QMS 和 3 天平均卡路里摄入量显著相关(p<0.05)。MSWT 距离与健康组的体重和体重指数显著相关(p<0.05)。
PCD 患儿从早期开始就存在无氧和有氧能力受损。年龄决定无氧能力。性别是有氧能力的决定因素。骨骼肌特征和与性别相关的身体成分变化是否影响 PCD 患儿的无氧和有氧能力,需要进一步研究。