Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Institute of Innovation for Future Society, Nagoya University, Nagoya, Japan.
Geriatr Gerontol Int. 2018 Jun;18(6):922-928. doi: 10.1111/ggi.13284. Epub 2018 Feb 28.
Physical activity (PA) and cognition have reportedly been associated with each other. However, it remains to be elucidated what intensities of PA are most strongly associated with cognition. In the current study, we aimed to determine the association between the intensities of objectively measured PA and cognitive function.
The present study was a cross-sectional analysis of the data obtained at registration in a randomized control trial in Toyota, Japan. Participants were community-dwelling older adults who had cognitive complaints. A battery of neuropsychological and physical assessments was carried out. Daily PA data were collected with the activity monitor. PA was categorized into one of three activity levels defined as light (<3.0 metabolic equivalents; LPA), moderate and vigorous (3.0 metabolic equivalents) activity. Partial correlation analysis was used to investigate the correlation between PA and cognition, with adjustments for age, sex and school years. We then carried out a multiple regression analysis to investigate the association of cognitive performance with PA, adjusting for insulin resistance or depressive mood.
Partial correlation adjusted for age, sex and schooling years showed that LPA was significantly correlated with the Digit Symbol Substitution test, Trail Making Test (TMT) part A and TMT-B, whereas moderate and vigorous activity showed no correlations. Multiple regression analysis with several models with different adjustments showed that LPA was associated with the Digit Symbol Substitution test, TMT-A and TMT-B independently from insulin resistance or depressive mood.
In the current study, we found that LPA was significantly associated with the performance of executive functional assessments. Geriatr Gerontol Int 2018; 18: 922-928.
体力活动（PA）和认知据称彼此相关。然而，仍然需要阐明与认知最密切相关的 PA 强度是多少。在目前的研究中，我们旨在确定客观测量的 PA 强度与认知功能之间的关联。
本研究是对日本丰田一项随机对照试验注册时获得的数据进行的横断面分析。参与者为有认知主诉的社区居住的老年人。进行了一系列神经心理学和身体评估。使用活动监测器收集日常 PA 数据。PA 分为三种活动水平之一，分别定义为低强度（<3.0 代谢当量；LPA）、中强度和高强度（3.0 代谢当量）活动。进行偏相关分析以调查 PA 与认知之间的相关性，调整年龄、性别和受教育年限。然后，我们进行了多元回归分析，以调查认知表现与 PA 的关联，调整胰岛素抵抗或抑郁情绪。
经年龄、性别和受教育年限调整的偏相关显示，LPA 与数字符号替代测试、TMT-A 和 TMT-B 显著相关，而中强度和高强度活动则没有相关性。使用具有不同调整的几个模型的多元回归分析表明，LPA 与数字符号替代测试、TMT-A 和 TMT-B 独立于胰岛素抵抗或抑郁情绪相关。
在目前的研究中，我们发现 LPA 与执行功能评估的表现显著相关。老年医学与老年病学国际 2018；18:922-928.
