Faculty of Psychology, Open University of the Netherlands, 6419 AT, Heerlen, the Netherlands.
Faculty of Educational Sciences, Open University of the Netherlands, 6419 AT, Heerlen, the Netherlands.
BMC Geriatr. 2021 Sep 4;21(1):478. doi: 10.1186/s12877-021-02429-x.
Regular physical activity (PA) is potentially beneficial for age-related cognitive decline. Although moderate-to-vigorous physical activity (MVPA) is mostly advised, older adults with chronic illnesses might benefit more from light physical activity (LPA), as they suffer from mobility problems, pain, and fatigue, limiting high-intensity PA. Therefore, the longitudinal association between change in LPA and MVPA and the change in cognitive functioning (CF) is investigated in older adults with chronic illnesses.
In total 432 older adults (mean age 73.7 [±6.1] years; 46.8% female) with at least one chronic illness participated in this longitudinal observational study. Longitudinal associations between accelerometer-assessed change in PA (LPA and MVPA) and change in CF, measured with an objective validated neuropsychological test battery, were tested with multivariate linear regressions.
An increase in LPA between baseline and 6 months follow-up was significantly associated with improved short-term verbal memory and inhibition over the first 6 months. In addition, the change score in LPA over the first 6 months was predictive for the change score in short-term verbal memory over 12 months. Furthermore, an increase in MVPA between baseline and 6 months follow-up was significantly associated with a decrease in longer-term verbal memory scores over the same six-month period.
For older adults with chronic illnesses who may experience difficulties in being sufficiently active, an increase in LPA is probably more achievable than an increase in MVPA. In addition, an increase in LPA enhances CF more than an increase in MVPA does.
Netherlands Trial Register NL6005 ; Date of Registration 21-03-2017.
有规律的身体活动（PA）可能对与年龄相关的认知能力下降有益。尽管建议进行中等至剧烈的身体活动（MVPA），但患有慢性病的老年人可能从低强度身体活动（LPA）中获益更多，因为他们存在行动问题、疼痛和疲劳，限制了高强度 PA。因此，本研究旨在调查患有慢性病的老年人中 LPA 和 MVPA 的变化与认知功能（CF）变化之间的纵向关联。
本研究共纳入 432 名患有至少一种慢性病的老年人（平均年龄 73.7 [±6.1] 岁；46.8%为女性），参与者参与了这项纵向观察性研究。采用多元线性回归分析，检验了加速度计评估的 PA（LPA 和 MVPA）变化与 CF 变化（使用客观验证的神经心理学测试组合测量）之间的纵向关联。
与基线相比，6 个月随访时 LPA 的增加与短期言语记忆和抑制的前 6 个月内的改善显著相关。此外，前 6 个月 LPA 的变化得分可预测 12 个月时短期言语记忆的变化得分。此外，与基线相比，6 个月随访时 MVPA 的增加与同一 6 个月内长期言语记忆得分的下降显著相关。
对于可能难以充分活跃的患有慢性病的老年人，增加 LPA 可能比增加 MVPA 更可行。此外，增加 LPA 比增加 MVPA 更能增强 CF。
荷兰试验注册 NL6005；注册日期 2017 年 3 月 21 日。
