Hamamatsu University School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Hi, Japan.
Hamamatsu Photonics K.K. Central Research Laboratory, Hamakitaku, Hamamatsu, Japan.
J Biomed Opt. 2018 Feb;23(2):1-6. doi: 10.1117/1.JBO.23.2.026010.
The purpose of this study was to evaluate the effects of the thickness and depth of tumors on hemoglobin measurements in breast cancer by optical spectroscopy and to demonstrate tissue oxygen saturation (SO2) and reduced scattering coefficient (μs') in breast tissue and breast cancer in relation to the skin-to-chest wall distance. We examined 53 tumors from 44 patients. Total hemoglobin concentration (tHb), SO2, and μs' were measured by time-resolved spectroscopy (TRS). The skin-to-chest wall distance and the size and depth of tumors were measured by ultrasonography. There was a positive correlation between tHb and tumor thickness, and a negative correlation between tHb and tumor depth. SO2 in breast tissue decreased when the skin-to-chest wall distance decreased, and SO2 in tumors tended to be lower than in breast tissue. In breast tissue, there was a negative correlation between μs' and the skin-to-chest wall distance, and μs' in tumors was higher than in breast tissue. Measurement of tHb in breast cancer by TRS was influenced by tumor thickness and depth. Although SO2 seemed lower and μs' was higher in breast cancer than in breast tissue, the skin-to-chest wall distance may have affected the measurements.
本研究旨在通过光声光谱评估肿瘤厚度和深度对乳腺癌血红蛋白测量的影响，并演示与皮肤-胸壁距离相关的乳房组织和乳腺癌中的组织氧饱和度 (SO2) 和减少散射系数 (μs')。我们检查了来自 44 名患者的 53 个肿瘤。通过时间分辨光谱法 (TRS) 测量总血红蛋白浓度 (tHb)、SO2 和 μs'。通过超声测量皮肤-胸壁距离以及肿瘤的大小和深度。tHb 与肿瘤厚度呈正相关，与肿瘤深度呈负相关。随着皮肤-胸壁距离的减小，乳房组织中的 SO2 降低，肿瘤中的 SO2 趋于低于乳房组织。在乳房组织中，μs' 与皮肤-胸壁距离呈负相关，而肿瘤中的 μs' 高于乳房组织。TRS 测量乳腺癌中的 tHb 受肿瘤厚度和深度的影响。尽管乳腺癌中的 SO2 似乎较低，μs' 较高，但皮肤-胸壁距离可能会影响测量结果。
