金黄色葡萄球菌菌血症患者合并菌尿症的临床意义。综述和荟萃分析。
The clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteremia. A review and meta-analysis.
机构信息
a Internal Medicine Department B , General Hospital of Heraklion 'Venizeleio-Pananeio' , Heraklion , Greece.
b General Medicine , University Hospital of Heraklion , Heraklion , Greece.
出版信息
Infect Dis (Lond). 2018 Sep;50(9):648-659. doi: 10.1080/23744235.2018.1445280. Epub 2018 Feb 28.
BACKGROUND
Staphylococcus aureus bacteriuria (SABU) concomitant to S. aureus bacteremia (SAB) has been associated with deep-seated infections and worse prognosis. However, the relevant studies were small and inconsistent. Here, we aim to provide a review of the relevant literature, and a meta-analysis of these studies.
METHODS
We searched PubMed and Scopus for studies comparing patients with SAB and concomitant SABU to patients with SAB without SABU.
RESULTS
Nine relevant studies were identified, involving 1429 patients with SAB, of whom 18.5% (n = 265) had concomitant SABU. Pooling the results of those studies, SABU was significantly associated with endocarditis, bone/joint infection and septic embolism. SABU was also associated with persistent SAB, and higher mortality.
CONCLUSIONS
Although SABU may be a useful marker of complicated SAB, the current literature has several limitations. Larger prospective studies are required to clarify the value of SABU in clinical decision making.
背景
金黄色葡萄球菌菌尿症（SABU）合并金黄色葡萄球菌菌血症（SAB）与深部感染和预后不良有关。然而，相关研究规模较小且结果不一致。本研究旨在对相关文献进行综述，并对这些研究进行荟萃分析。
方法
我们在 PubMed 和 Scopus 上检索了比较伴有和不伴有 SABU 的 SAB 患者的研究。
结果
共纳入 9 项相关研究，涉及 1429 例 SAB 患者，其中 18.5%（n=265）合并 SABU。对这些研究的结果进行汇总分析，SABU 与心内膜炎、骨/关节感染和脓毒性栓塞显著相关。SABU 还与持续性 SAB 和更高的死亡率相关。
结论
尽管 SABU 可能是严重 SAB 的有用标志物，但目前的文献存在一些局限性。需要更大规模的前瞻性研究来阐明 SABU 在临床决策中的价值。
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