Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Int J Infect Dis. 2020 Sep;98:467-469. doi: 10.1016/j.ijid.2020.07.022. Epub 2020 Jul 25.
Staphylococcus aureus bacteriuria (SABU) is rare but can be an indicator of S. aureus bacteremia (SAB). The objective of this study was to assess the proportion of SAB in patients with SABU and identify risk factors in a hospital-based population.
We used electronic databases to identify eligible patients to be enrolled in a retrospective cohort study. Inclusion criteria were (i) SABU, (ii) ≥18 years of age, and (iii) ≥1 blood culture sampled ±3 months of SABU. Patients with missing values for demographic (e.g., age, sex) or clinical characteristics (e.g., comorbidities) and laboratory analyses were excluded.
In total, 245 patients attending the University Hospital Münster, Germany, between 1 January 2012 and 31 December 2019 met the inclusion/exclusion criteria. Of the 245 patients with SABU, 66 had a concomitant SAB (26.9%). Elevated C-reactive protein (CRP) levels were associated with SAB. Other parameters (e.g., leukocytes, comorbidities) were not associated with SAB in a multivariate analysis.
The frequency of SAB in patients with SABU was high and warrants active screening for bloodstream infections in hospitalized patients, particularly if CRP levels are elevated.
金黄色葡萄球菌菌尿症（SABU）较为罕见，但可能是金黄色葡萄球菌菌血症（SAB）的一个指标。本研究的目的是评估 SABU 患者中 SAB 的比例，并确定医院人群中的危险因素。
我们使用电子数据库来确定符合条件的患者，以进行回顾性队列研究。纳入标准为：（i）SABU，（ii）年龄≥18 岁，（iii）SABU 前后≥1 次血培养。排除了在人口统计学（如年龄、性别）或临床特征（如合并症）和实验室分析方面存在缺失值的患者。
2012 年 1 月 1 日至 2019 年 12 月 31 日期间，德国明斯特大学医院共有 245 名符合纳入/排除标准的 SABU 患者。在 245 名 SABU 患者中，有 66 名同时患有 SAB（26.9%）。C 反应蛋白（CRP）水平升高与 SAB 相关。在多变量分析中，其他参数（如白细胞、合并症）与 SAB 无相关性。
SABU 患者中 SAB 的频率较高，需要对住院患者进行积极筛查血液感染，尤其是 CRP 水平升高时。
