Calain P, Krause K H, Vaudaux P, Auckenthaler R, Lew D, Waldvogel F, Hirschel B
J Infect Dis. 1987 Feb;155(2):187-91. doi: 10.1093/infdis/155.2.187.
In a prospective, randomized trial, teicoplanin (at a 400-mg intravenous loading dose followed by 200 mg/day intravenously or intramuscularly) was compared with flucloxacillin (8 g/day) in patients with severe staphylococcal infections. Teicoplanin proved unsatisfactory for the following reasons: failures or relapses were more frequent in the teicoplanin group, and blood levels were difficult to predict and tended to be low 24 hr after the loading dose. Future trials with this agent should use much-higher doses.
在一项前瞻性随机试验中，对患有严重葡萄球菌感染的患者，将替考拉宁（静脉注射负荷剂量400mg，随后静脉或肌肉注射200mg/天）与氟氯西林（8g/天）进行了比较。替考拉宁被证明效果不佳，原因如下：替考拉宁组失败或复发更为频繁，且血药浓度难以预测，在负荷剂量后24小时往往较低。未来使用该药物的试验应采用更高剂量。
