Department of Surgical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
BMC Microbiol. 2023 Jan 6;23(1):5. doi: 10.1186/s12866-022-02753-1.
Enterococcus faecalis remains one of the most common pathogens causing infection in surgical patients. Our goal was to evaluate the antibiotic resistance of E. faecalis, causing infections in a surgical clinic, against two antibacterial drugs, ampicillin and teicoplanin. One commonly administered in the past for such infections, ampicillin, and another newer, teicoplanin, which demonstrated exceptionally good efficacy.
Data from 1882 isolates were retrieved from the microbiology department database during two 5-year periods. Standard biochemical methods were employed for the identification of the isolates. The prevalence of E. faecalis among patients with clinical evidence of infection in a surgical oncology ward was assessed. Confidence interval (CI) as well as standard error (SE) were calculated. Moreover, the annual incidence of E. faecalis infections in this surgical ward was recorded. The susceptibility of E. faecalis to ampicillin and teicoplanin was studied and compared using Fisher's exact test.
Results showed that the incidence of E. faecalis infections in the surgical clinic was increasing. Ampicillin, in the later year period, was not statistically different from teicoplanin in treating E. faecalis infections. Consequently, ampicillin seems currently to be an effective antibiotic against such infections that could be used as empiric therapy.
粪肠球菌仍然是导致外科患者感染的最常见病原体之一。我们的目标是评估引起外科诊所感染的粪肠球菌对两种抗菌药物氨苄西林和替考拉宁的耐药性。氨苄西林是过去常用于治疗此类感染的药物，而替考拉宁是一种较新的药物，具有非常好的疗效。
从两个 5 年期间的微生物部门数据库中检索了 1882 株分离株的数据。采用标准生化方法鉴定分离株。评估外科肿瘤病房有临床感染证据的患者中粪肠球菌的流行情况。计算了置信区间 (CI) 和标准误差 (SE)。此外，还记录了该外科病房中粪肠球菌感染的年发生率。使用 Fisher 确切检验研究并比较了粪肠球菌对氨苄西林和替考拉宁的敏感性。
结果表明，外科诊所中粪肠球菌感染的发生率正在增加。在后期阶段，氨苄西林在治疗粪肠球菌感染方面与替考拉宁无统计学差异。因此，氨苄西林目前似乎是一种有效的治疗此类感染的抗生素，可以作为经验性治疗。
