Premel-Cabic A, Gétin F, Turcant A, Rohmer V, Bigorgne J C, Allain P
Presse Med. 1986 Sep 27;15(32):1625-7.
Plasma noradrenaline concentrations (NA) were measured in 11 hypothyroid patients, 24 hypothyroid patients and 30 normal subjects after 30 minutes of supine rest and after 5 minutes of standing. Observed noradrenaline levels, after rest as well as after standing, were significantly higher in hypothyroid patients (NA rest = 0.66 +/- 0.35 microgram/l, NA standing = 1.26 +/- 0.70 micrograms/l) and significantly lower in hyperthyroid patients (NA rest = 0.22 +/- 0.13 micrograms/l, NA standing = 0.37 +/- 0.20 microgram/l) than in normal subjects (NA rest = 0.32 +/- 0.13 microgram/l, NA standing = 0.55 +/- 0.20 microgram/l). The increase in noradrenaline with standing, when expressed in percent, was similar for the three groups studied (about 100%). These results suggest that a sympathetic nervous system adaptation occurs in hyperthyroidism and hypothyroidism as a compensatory phenomenon to the direct effect of thyroid hormones on the heart.
在11名甲状腺功能减退患者、24名甲状腺功能亢进患者和30名正常受试者仰卧休息30分钟及站立5分钟后，测量其血浆去甲肾上腺素浓度（NA）。在休息及站立后，甲状腺功能减退患者的去甲肾上腺素水平明显更高（休息时NA = 0.66±0.35微克/升，站立时NA = 1.26±0.70微克/升），而甲状腺功能亢进患者的去甲肾上腺素水平明显更低（休息时NA = 0.22±0.13微克/升，站立时NA = 0.37±0.20微克/升），均与正常受试者（休息时NA = 0.32±0.13微克/升，站立时NA = 0.55±0.20微克/升）不同。在研究的三组中，站立时去甲肾上腺素增加的百分比相似（约100%）。这些结果表明，作为甲状腺激素对心脏直接作用的一种代偿现象，甲状腺功能亢进和甲状腺功能减退时会出现交感神经系统适应性变化。
