Fénelon Mathilde, Castet Sabine, Fricain Jean-Christophe, Catros Sylvain
Department of Dentistry and Oral Health, University Hospital of Bordeaux, Bordeaux, France.
Inserm U1026, BioIngénierie Tissulaire, University of Bordeaux, Bordeaux, France.
Open Dent J. 2018 Jan 31;12:80-86. doi: 10.2174/1874210601812010080. eCollection 2018.
Von Willebrand Disease is the most common inherited bleeding disorder. In the general population, 1/8000 patients are affected. Primary hemostasis (platelet adhesion) and coagulation (protection of Factor VIII) are altered. Among several bleeding symptoms, these patients suffer from excessive bleeding of oral mucosa and dental management requires a close collaboration between haematologists and oral surgeons.
MATERIALS & METHODS: Guided implant surgery can be used to increase the accuracy of implant placement and to reduce the overall morbidity of this surgical procedure by using a flapless surgery technique.
We report the case of a 49 years old woman having a Type 2A von Willebrand disease and who presented to replace tooth #.46 because of interradicular fracture and peri-apical infection. After planning the implant surgery using Codiagnostix software, a surgical guide was prepared. The patient received 4 injections of von Willebrand factor (Willfactin) for this particular surgical procedure. The implant was placed immediately after tooth removal and local haemostasis was performed.
The follow-up was uneventful and the implant was restored by a crown 4 months later. Two cases of implant placement in haemophiliac patients have been reported before in the literature.
As far as we know, this is the first case report of implant placement in a patient having a von Willebrand disease. The use of guided surgery allowed to perform a mini-invasive procedure and thus contributed to prevent bleeding complications in this patient.
血管性血友病是最常见的遗传性出血性疾病。在普通人群中,每8000名患者中就有1人患病。初级止血(血小板黏附)和凝血(因子VIII的保护)会发生改变。在多种出血症状中,这些患者会出现口腔黏膜过度出血,牙科治疗需要血液科医生和口腔外科医生密切合作。
引导式种植手术可用于提高种植体植入的准确性,并通过使用无瓣手术技术降低该手术的总体发病率。
我们报告了一例49岁女性患者,患有2A型血管性血友病,因根间骨折和根尖周感染前来拔除46号牙。使用Codiagnostix软件规划种植手术后,制作了手术导板。该患者因这一特定手术接受了4次血管性血友病因子(威尔法汀)注射。拔牙后立即植入种植体并进行局部止血。
随访过程顺利,4个月后用牙冠修复了种植体。此前文献中曾报道过2例血友病患者的种植体植入病例。
据我们所知,这是首例血管性血友病患者种植体植入的病例报告。引导式手术的使用使得手术能够微创进行,从而有助于预防该患者的出血并发症。