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本文引用的文献

1
Retrospective Multivariate Clinical Analysis of 2707 Dental Implants with Hydrophilic and Hydrophobic Surfaces: Survival Rates after Up to 5 Years.亲水和疏水表面 2707 颗种植体的回顾性多因素临床分析:长达 5 年的生存率。
J Long Term Eff Med Implants. 2022;32(1):65-71. doi: 10.1615/JLongTermEffMedImplants.2021039884.
2
Prospective observational study on the clinical behaviour of dental implants in patients with haemophilia. Preliminary results.前瞻性观察研究血友病患者中牙种植体的临床行为。初步结果。
Br J Oral Maxillofac Surg. 2022 Feb;60(2):157-161. doi: 10.1016/j.bjoms.2021.03.014. Epub 2021 Mar 31.
3
Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence-based practice? A review of the literature.关于血友病患者拔牙的现状:共识还是循证实践?文献综述。
Haemophilia. 2020 Mar;26(2):183-199. doi: 10.1111/hae.13928. Epub 2020 Jan 21.
4
Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.抗纤维蛋白溶解疗法用于预防血友病或血管性血友病患者在接受小型口腔手术或拔牙时的口腔出血。
Cochrane Database Syst Rev. 2019 Apr 19;4(4):CD011385. doi: 10.1002/14651858.CD011385.pub3.
5
Dental management of patients with haemophilia in the era of recombinant treatments: increased efficacy and decreased clinical risk.重组治疗时代血友病患者的牙科管理:疗效提高且临床风险降低。
BMJ Case Rep. 2019 Apr 8;12(4):e227974. doi: 10.1136/bcr-2018-227974.
6
Infected tooth extraction, bone grafting, immediate implant placement and immediate temporary crown insertion in a patient with severe type-B hemophilia.对一名重度B型血友病患者进行感染牙齿拔除、骨移植、即刻种植体植入及即刻临时牙冠安置术。
BMJ Case Rep. 2019 Mar 22;12(3):e229204. doi: 10.1136/bcr-2019-229204.
7
Influence of different implant-abutment connection designs on the mechanical and biological behavior of single-tooth implants in the maxillary esthetic zone: A systematic review.不同种植体-基台连接设计对上颌美学区单牙种植体机械和生物学行为的影响:系统评价。
J Prosthet Dent. 2019 Mar;121(3):398-403.e3. doi: 10.1016/j.prosdent.2018.05.007. Epub 2018 Nov 23.
8
Dental Implant Therapy on a Patient With von Willebrand Disease: A Case Study.《伴 von Willebrand 病患者的牙种植治疗:病例研究》。
Implant Dent. 2018 Oct;27(5):599-601. doi: 10.1097/ID.0000000000000821.
9
Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report.引导式种植手术降低血管性血友病患者的发病率:病例报告
Open Dent J. 2018 Jan 31;12:80-86. doi: 10.2174/1874210601812010080. eCollection 2018.
10
Oral Surgery in Patients With Glanzmann Thrombasthenia: A Case Series.患有Glanzmann血小板无力症患者的口腔外科手术:病例系列
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遗传性凝血障碍患者种植体存活率及边缘骨吸收的 2 年回顾性观察性病例对照研究。

2-years retrospective observational case-control study on survival and marginal bone loss of implants in patients with hereditary coagulopathies.

机构信息

School of Dentistry c/ Avicena s/n. 41009, Sevilla

出版信息

Med Oral Patol Oral Cir Bucal. 2023 Nov 1;28(6):e572-e580. doi: 10.4317/medoral.25997.

DOI:10.4317/medoral.25997
PMID:37099709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10635626/
Abstract

BACKGROUND

Evaluating 2-years implant loss and marginal bone loss in patients with hereditary coagulopathies, comparing with a healthy control group.

MATERIAL AND METHODS

37 implants in 13 patients (17 haemophilia A, 20 Von-Willebrand disease) versus 26 implants in 13 healthy patients. Data measured through Lagervall-Jansson index (after surgery, at prosthetic loading, at 2 years).

STATISTICS

Chi-square, Haberman's, ANOVA, Mann-Whitney-U. Significance p<0.05.

RESULTS

Haemorrhagic accidents in 2 coagulopathies patients (non-statistical differences). Hereditary coagulopathies patients suffered more hepatitis (p<0.05), HIV (p<0.05) and less previous periodontitis (p<0.01). Non-statistical differences in marginal bone loss among groups. 2 implants were lost in the hereditary coagulopathies and none in the control group (non-statistical differences). Hereditary coagulopathies patients had longer (p<0.001), and narrower implants (p<0.05) placed. 43.2% external prosthetic connection in hereditary coagulopathies patients (p<0.001); change of prosthetic platform more frequent in control group (p<0.05). 2 implants lost: external connection (p<0.05). Survival rate 96.8% (hereditary coagulopathies 94.6%, control group 100%).

CONCLUSIONS

Implant and marginal bone loss at 2 years is similar in patients with hereditary coagulopathies and control group. Precautions should be taken on the treatment for hereditary coagulopathies patients, through prior haematological protocol. Implant loss only occurred in in a patient with Von-Willebrand´s disease.

摘要

背景

评估遗传性凝血障碍患者与健康对照组患者的 2 年种植体丧失和边缘骨丧失。

材料与方法

13 名患者(17 例血友病 A,20 例血管性血友病)共 37 枚种植体,与 13 名健康患者的 26 枚种植体相比。数据通过 Lagervall-Jansson 指数(术后、修复体加载后、2 年后)进行测量。

统计

卡方检验、哈伯曼检验、方差分析、Mann-Whitney-U 检验。显著性水平 p<0.05。

结果

2 名凝血障碍患者发生出血事件(无统计学差异)。遗传性凝血障碍患者更多患有肝炎(p<0.05)、HIV(p<0.05),且牙周炎病史较少(p<0.01)。各组间边缘骨丧失无统计学差异。遗传性凝血障碍组有 2 枚种植体脱落,对照组无种植体脱落(无统计学差异)。遗传性凝血障碍患者的种植体更长(p<0.001)、更窄(p<0.05)。遗传性凝血障碍患者有 43.2%的外部修复体连接(p<0.001);对照组中修复体平台改变更频繁(p<0.05)。2 枚种植体脱落:外部连接(p<0.05)。存活率为 96.8%(遗传性凝血障碍组为 94.6%,对照组为 100%)。

结论

遗传性凝血障碍患者与对照组患者在 2 年内的种植体和边缘骨丧失相似。对遗传性凝血障碍患者的治疗应采取预防措施,通过预先的血液学方案。仅 1 例血管性血友病患者发生种植体脱落。