School of Dentistry c/ Avicena s/n. 41009, Sevilla
Med Oral Patol Oral Cir Bucal. 2023 Nov 1;28(6):e572-e580. doi: 10.4317/medoral.25997.
Evaluating 2-years implant loss and marginal bone loss in patients with hereditary coagulopathies, comparing with a healthy control group.
37 implants in 13 patients (17 haemophilia A, 20 Von-Willebrand disease) versus 26 implants in 13 healthy patients. Data measured through Lagervall-Jansson index (after surgery, at prosthetic loading, at 2 years).
Chi-square, Haberman's, ANOVA, Mann-Whitney-U. Significance p<0.05.
Haemorrhagic accidents in 2 coagulopathies patients (non-statistical differences). Hereditary coagulopathies patients suffered more hepatitis (p<0.05), HIV (p<0.05) and less previous periodontitis (p<0.01). Non-statistical differences in marginal bone loss among groups. 2 implants were lost in the hereditary coagulopathies and none in the control group (non-statistical differences). Hereditary coagulopathies patients had longer (p<0.001), and narrower implants (p<0.05) placed. 43.2% external prosthetic connection in hereditary coagulopathies patients (p<0.001); change of prosthetic platform more frequent in control group (p<0.05). 2 implants lost: external connection (p<0.05). Survival rate 96.8% (hereditary coagulopathies 94.6%, control group 100%).
Implant and marginal bone loss at 2 years is similar in patients with hereditary coagulopathies and control group. Precautions should be taken on the treatment for hereditary coagulopathies patients, through prior haematological protocol. Implant loss only occurred in in a patient with Von-Willebrand´s disease.
评估遗传性凝血障碍患者与健康对照组患者的 2 年种植体丧失和边缘骨丧失。
13 名患者(17 例血友病 A,20 例血管性血友病)共 37 枚种植体,与 13 名健康患者的 26 枚种植体相比。数据通过 Lagervall-Jansson 指数(术后、修复体加载后、2 年后)进行测量。
卡方检验、哈伯曼检验、方差分析、Mann-Whitney-U 检验。显著性水平 p<0.05。
2 名凝血障碍患者发生出血事件(无统计学差异)。遗传性凝血障碍患者更多患有肝炎(p<0.05)、HIV(p<0.05),且牙周炎病史较少(p<0.01)。各组间边缘骨丧失无统计学差异。遗传性凝血障碍组有 2 枚种植体脱落,对照组无种植体脱落(无统计学差异)。遗传性凝血障碍患者的种植体更长(p<0.001)、更窄(p<0.05)。遗传性凝血障碍患者有 43.2%的外部修复体连接(p<0.001);对照组中修复体平台改变更频繁(p<0.05)。2 枚种植体脱落:外部连接(p<0.05)。存活率为 96.8%(遗传性凝血障碍组为 94.6%,对照组为 100%)。
遗传性凝血障碍患者与对照组患者在 2 年内的种植体和边缘骨丧失相似。对遗传性凝血障碍患者的治疗应采取预防措施,通过预先的血液学方案。仅 1 例血管性血友病患者发生种植体脱落。