Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Department of Urology, Nanyang Second General Hospital, Nanyang 473012, China.
Asian J Androl. 2018 Jul-Aug;20(4):366-371. doi: 10.4103/aja.aja_5_18.
We evaluated the prognosis of the new grade groups and American Joint Committee on Cancer (AJCC) stage groups in men with prostate cancer (PCa) who were treated conservatively. A total of 13 798 eligible men were chosen from the Surveillance Epidemiology and End Results database. The new grade and AJCC stage groups were investigated on prostate biopsy specimens. Kaplan-Meier survival analysis and multivariable hazards models were applied to estimate the association of new grade and stage groups with overall survival (OS) and PCa-specific survival (CSS). Mean follow-up was 42.65 months (95% confidence interval: 42.47-42.84) in the entire cohort. The 3-year OS and CSS rates stepped down for grade groups 1-5 and AJCC stage groups I-IVB, respectively. After adjusting for clinical and pathological characteristics, all grade groups and AJCC stage groups were associated with higher all-cause and PCa-specific mortality compared to the reference group (all P ≤ 0.003). In conclusion, we evaluated the oncological outcome of the new grade and AJCC stage groups on biopsy specimens of conservatively treated PCa. These two novel clinically relevant classifications can assist physicians to determine different therapeutic strategies for PCa patients.
我们评估了新分级组和美国癌症联合委员会（AJCC）分期组在接受保守治疗的前列腺癌（PCa）男性患者中的预后。从监测、流行病学和最终结果数据库中选择了总共 13798 名符合条件的男性。新的分级和 AJCC 分期组在前列腺活检标本上进行了研究。Kaplan-Meier 生存分析和多变量风险模型用于估计新分级和分期组与总生存（OS）和 PCa 特异性生存（CSS）的相关性。整个队列的平均随访时间为 42.65 个月（95%置信区间：42.47-42.84）。3 年 OS 和 CSS 率分别逐降为分级组 1-5 和 AJCC 分期组 I-IVB。在校正了临床和病理特征后，与参考组相比，所有分级组和 AJCC 分期组与全因和 PCa 特异性死亡率升高相关（均 P≤0.003）。总之，我们评估了新分级和 AJCC 分期组在保守治疗的 PCa 活检标本上的肿瘤学结果。这两种新的具有临床相关性的分类方法可以帮助医生为 PCa 患者确定不同的治疗策略。
