Shawki Sherief, Ashburn Jean, Signs Steven A, Huang Emina
Department of Colorectal Surgery, Cleveland Clinic, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland Clinic Lerner Research Institute, NE3, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Surg Oncol Clin N Am. 2018 Apr;27(2):269-287. doi: 10.1016/j.soc.2017.11.003. Epub 2017 Dec 15.
Colitis-associated cancer is a relatively rare form of cancer with an unclear pathogenesis. Colitis-associated cancer serves as a prototype of inflammation-associated cancers. Advanced colonoscopic techniques are considered standard of care for surveillance in patients with long-standing colitis, especially those with other risk factors, including sclerosing cholangitis and a family history of colorectal cancer. When colitis-associated cancer is diagnosed, the standard operation involves total proctocolectomy. Restorative procedures and surveillance after colectomy require special considerations. In these contexts, new 3-dimensional human models may be used to usher in personalized medicine.
结肠炎相关癌是一种相对罕见的癌症，其发病机制尚不清楚。结肠炎相关癌是炎症相关癌症的一个典型例子。先进的结肠镜检查技术被认为是长期结肠炎患者监测的标准治疗方法，尤其是那些有其他风险因素的患者，包括硬化性胆管炎和结直肠癌家族史。当诊断出结肠炎相关癌时，标准手术包括全直肠结肠切除术。结肠切除术后的恢复性手术和监测需要特殊考虑。在这些情况下，新的三维人体模型可用于引入个性化医疗。
