• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

柠檬苦素通过调节脂多糖诱导的巨噬细胞中的NF-κB信号通路发挥抗炎作用。

limonoid plays anti-inflammatory role by regulating NF-B signaling pathway in lipopolysaccharide-induced macrophages.

作者信息

Shen Jinhuang, Cao Fan, Huang Zhiyong, Ma Xinhua, Yang Nana, Zhang Haitao, Zhang Yonghong, Zhang Zhiqiang

机构信息

Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Department of Pharmacy, Fujian Medical University, Fuzhou, China.

Department of Plastic Surgery, Dermatology Hospital of Fuzhou, Fuzhou, China.

出版信息

Food Nutr Res. 2023 Jul 14;67. doi: 10.29219/fnr.v67.9383. eCollection 2023.

DOI:10.29219/fnr.v67.9383
PMID:37533446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10392864/
Abstract

BACKGROUND

a well-known tropical tree native to southeastern China, has anti-inflammatory and antioxidant activities, and contains large amounts of limonoids and triterpenoids.

OBJECTIVE

The aim of this study was to investigate the potential anti-inflammatory activity of limonoids from on lipopolysaccharide (LPS)-mediated RAW264.7 cells.

METHODS AND RESULTS

Using a bioassay-guided approach, the chemical fraction with high anti-inflammatory activity was found and its chemical constituents were investigated. Phytochemical studies on active extracts resulted in the separation of three novel phragmalin limonoids (-), together with two known limonoids (-) and 11 tirucallane triterpenes (-). The activity of these isolated compounds in the production of nitric oxide (NO) on LPS-reated macrophages was evaluated. Limonoid indicated significant anti-inflammatory activities with IC value of 4.58 M. Limonoid notably inhibited the production of NO, interleukin- 6 and tumor necrosis factor- on macrophage. Signal transduction and activation of STAT and NF-B activators were effectively blocked by limonoid .

CONCLUSIONS

These results indicate that limonoid has an anti-inflammatory effect by the inhibiting JAK2/STAT3, iNOS/eNOS, and NF-B signaling pathways and regulating inflammatory mediators.

摘要

背景

一种原产于中国东南部的著名热带树木，具有抗炎和抗氧化活性，并且含有大量柠檬苦素和三萜类化合物。

目的

本研究旨在探讨从该植物中提取的柠檬苦素对脂多糖（LPS）介导的RAW264.7细胞的潜在抗炎活性。

方法与结果

采用生物活性导向法，发现了具有高抗炎活性的化学组分并对其化学成分进行了研究。对活性提取物进行植物化学研究，分离出三种新型苦楝素类柠檬苦素（-），以及两种已知的柠檬苦素（-）和11种四环三萜（-）。评估了这些分离化合物对LPS刺激的巨噬细胞中一氧化氮（NO）产生的活性。柠檬苦素显示出显著的抗炎活性，IC值为4.58μM。柠檬苦素显著抑制巨噬细胞中NO、白细胞介素-6和肿瘤坏死因子-的产生。柠檬苦素有效地阻断了信号转导以及STAT和NF-κB激活剂的激活。

结论

这些结果表明，柠檬苦素通过抑制JAK2/STAT3、iNOS/eNOS和NF-κB信号通路并调节炎症介质发挥抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/9f8eb5f31070/FNR-67-9383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/f4ca1bf12115/FNR-67-9383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/0122a48683fe/FNR-67-9383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/461c2c00e034/FNR-67-9383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/78f983246543/FNR-67-9383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/c3a7a5757317/FNR-67-9383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/9f8eb5f31070/FNR-67-9383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/f4ca1bf12115/FNR-67-9383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/0122a48683fe/FNR-67-9383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/461c2c00e034/FNR-67-9383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/78f983246543/FNR-67-9383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/c3a7a5757317/FNR-67-9383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b4/10392864/9f8eb5f31070/FNR-67-9383-g006.jpg

相似文献

1
limonoid plays anti-inflammatory role by regulating NF-B signaling pathway in lipopolysaccharide-induced macrophages.柠檬苦素通过调节脂多糖诱导的巨噬细胞中的NF-κB信号通路发挥抗炎作用。
Food Nutr Res. 2023 Jul 14;67. doi: 10.29219/fnr.v67.9383. eCollection 2023.
2
Bioactivity-guided isolation of anti-inflammatory limonins from .从……中进行生物活性导向的抗炎柠檬苦素分离。 （你提供的原文不完整，这里只是按完整句子的翻译思路给出大致译文，需补充完整原文才能准确翻译。）
Food Sci Nutr. 2022 Aug 9;10(12):4216-4225. doi: 10.1002/fsn3.3015. eCollection 2022 Dec.
3
Phragmalin-Type Limonoids from the Fruits of and Their Anti-Inflammatory Activity.栝楼素型柠檬苦素类化合物及其抗炎活性研究。
Molecules. 2023 Jun 30;28(13):5136. doi: 10.3390/molecules28135136.
4
Phragmalin-type limonoids with NF-κB inhibition from Chukrasia tabularis var. velutina.从毛麻楝中分离得到的具有NF-κB抑制活性的苦楝素型柠檬苦素。
Bioorg Med Chem Lett. 2014 Aug 15;24(16):3791-6. doi: 10.1016/j.bmcl.2014.06.069. Epub 2014 Jun 28.
5
Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss.从 Tabularia 树的种子中分离得到的 Phragmalin 和墨西哥醇 Limonoids，具有逆转多药耐药性的作用。
Phytochemistry. 2021 Feb;182:112606. doi: 10.1016/j.phytochem.2020.112606. Epub 2020 Dec 11.
6
Twelve novel and diverse 16-norphragmalin-type limonoids from Chukrasia tabularis var. velutina.从毛红椿中分离得到的12种新颖且多样的16-降苦楝素型柠檬苦素。
Chem Pharm Bull (Tokyo). 2012;60(2):195-204. doi: 10.1248/cpb.60.195.
7
Six New Phragmalin Limonoids from the Stems of A. Juss.六种新的黄玉兰属 Limonoids 来自 A. Juss. 的茎部
Molecules. 2018 Nov 20;23(11):3024. doi: 10.3390/molecules23113024.
8
Two new phragmalin-type limonoids from Chukrasia tabularis and their α-glucosidase inhibitory activity.从毛麻楝中分离得到的两种新的苦楝素型柠檬苦素及其α-葡萄糖苷酶抑制活性。
J Asian Nat Prod Res. 2016 Jul;18(7):629-36. doi: 10.1080/10286020.2015.1136291. Epub 2016 Feb 3.
9
New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity.来自毛麻楝的新型苦楝素类柠檬苦素及其α-葡萄糖苷酶抑制活性。
Molecules. 2016 Jan 5;21(1):58. doi: 10.3390/molecules21010058.
10
Phragmalin-type limonoids with structural diversity at D-ring from the fruit shells of Chukrasia tabularis.来自长果山麻杆果壳的具有 D 环结构多样性的黄烷型柠檬苦素。
Fitoterapia. 2019 Apr;134:188-195. doi: 10.1016/j.fitote.2019.02.032. Epub 2019 Feb 28.

引用本文的文献

1
Antioxidant, Antimicrobial, and Anti-Inflammatory Effects of Leaves.树叶的抗氧化、抗菌和抗炎作用。
ACS Omega. 2024 Jun 10;9(25):27002-27016. doi: 10.1021/acsomega.3c10269. eCollection 2024 Jun 25.

本文引用的文献

1
Bioactivity-guided isolation of anti-inflammatory limonins from .从……中进行生物活性导向的抗炎柠檬苦素分离。 （你提供的原文不完整，这里只是按完整句子的翻译思路给出大致译文，需补充完整原文才能准确翻译。）
Food Sci Nutr. 2022 Aug 9;10(12):4216-4225. doi: 10.1002/fsn3.3015. eCollection 2022 Dec.
2
The Selective Serotonin 2A Receptor Antagonist Sarpogrelate Prevents Cardiac Hypertrophy and Systolic Dysfunction via Inhibition of the ERK1/2-GATA4 Signaling Pathway.选择性5-羟色胺2A受体拮抗剂沙格雷酯通过抑制ERK1/2-GATA4信号通路预防心脏肥大和收缩功能障碍。
Pharmaceuticals (Basel). 2021 Dec 5;14(12):1268. doi: 10.3390/ph14121268.
3
Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease.
靶向 JAK/STAT 信号通路治疗炎症性肠病。
Inflamm Res. 2021 Jul;70(7):753-764. doi: 10.1007/s00011-021-01482-x. Epub 2021 Jul 1.
4
Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation.胡椒碱通过减弱MAPKs/NF-κB信号通路和NLRP3炎性小体激活对脂多糖诱导的脓毒症的保护作用。
Pharmaceuticals (Basel). 2021 Jun 18;14(6):588. doi: 10.3390/ph14060588.
5
Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.清血解毒方通过抑制 STAT3/MAPK/NF-κB 信号通路改善 DNFB 诱导的特应性皮炎。
J Ethnopharmacol. 2021 Apr 24;270:113773. doi: 10.1016/j.jep.2020.113773. Epub 2020 Dec 31.
6
Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action.白芍总苷：对其植物化学、在自身免疫性疾病中的作用和作用机制的综述。
J Ethnopharmacol. 2020 Aug 10;258:112913. doi: 10.1016/j.jep.2020.112913. Epub 2020 May 1.
7
Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana.来自长圆叶杜茎山的具有潜在抗炎活性的 clerodane 二萜。
Chin J Nat Med. 2019 Dec;17(12):953-962. doi: 10.1016/S1875-5364(19)30118-9.
8
New tirucallane triterpenoids from Picrasma quassioides with their potential antiproliferative activities on hepatoma cells.来自算盘子的新的三萜类化合物及其对肝癌细胞的潜在抗增殖活性。
Bioorg Chem. 2019 Mar;84:309-318. doi: 10.1016/j.bioorg.2018.11.049. Epub 2018 Nov 28.
9
Nitric oxide inhibitory limonoids as potential anti-neuroinflammatory agents from Swietenia mahagoni.从桃花心木中提取的具有抑制一氧化氮作用的柠檬苦素类化合物可能成为抗神经炎症的药物。
Bioorg Chem. 2019 Mar;84:177-185. doi: 10.1016/j.bioorg.2018.11.012. Epub 2018 Nov 19.
10
Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways.没食子酰基原花青素 B2 对大鼠三硝基苯磺酸诱导的急性结肠炎发展的预防作用与抑制炎症介质和 NLRP3/ASC 炎性小体信号通路有关。
Chem Biol Interact. 2019 Jan 5;297:25-33. doi: 10.1016/j.cbi.2018.10.020. Epub 2018 Oct 23.