Sahin Nilfer, Altun Hatice, Kurutas Ergül Belge, Balkan Damla
Department of Child and Adolescent Psychiatry, Muğla Sıtkı Koçman University, Muğla, Turkey.
Department of Child and Adolescent Psychiatry, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Neuropsychiatr Dis Treat. 2018 Feb 19;14:581-585. doi: 10.2147/NDT.S158228. eCollection 2018.
In this study, we aimed to evaluate vitamin D and vitamin D receptor levels in children with attention-deficit/hyperactivity disorder (ADHD).
In this cross-sectional study, a total of 80 children including 40 ADHD patients (aged 6-12 years; 28 males and 12 females) and 40 age-, sex-, and season of blood collection-matched controls (aged 6-12 years; 25 males and 15 females) were enrolled. Serum vitamin D and vitamin D receptor levels and calcium, phosphorus, and alkaline phosphatase were measured. The vitamin D receptor levels in the serum were measured using the quantitative sandwich enzyme immunoassay technique.
Serum vitamin D and vitamin D receptor levels were found to be significantly lower in children with ADHD compared to healthy controls. No significant differences were found in serum calcium, phosphorus, and alkaline phosphatase levels. No significant differences were found among the ADHD subtypes in terms of serum vitamin D, vitamin D receptor, calcium, phosphorus and alkaline phosphatase levels.
This study suggests that children with ADHD have lower levels of vitamin D and vitamin D receptor. According to the authors' knowledge, this is the first study to describe vitamin D receptor levels in ADHD.
在本研究中，我们旨在评估注意力缺陷多动障碍（ADHD）患儿的维生素D及维生素D受体水平。
在这项横断面研究中，共纳入80名儿童，其中包括40例ADHD患儿（年龄6至12岁；男28例，女12例）以及40名年龄、性别和采血季节相匹配的对照儿童（年龄6至12岁；男25例，女15例）。检测血清维生素D、维生素D受体水平以及钙、磷和碱性磷酸酶。采用定量夹心酶免疫测定技术检测血清中的维生素D受体水平。
发现ADHD患儿的血清维生素D和维生素D受体水平显著低于健康对照。血清钙、磷和碱性磷酸酶水平未发现显著差异。ADHD各亚型之间在血清维生素D、维生素D受体、钙、磷和碱性磷酸酶水平方面未发现显著差异。
本研究表明，ADHD患儿的维生素D和维生素D受体水平较低。据作者所知，这是第一项描述ADHD中维生素D受体水平的研究。
