Staniszewska Marzena, Dziedziejko Violetta, Kwiatkowska Ewa, Tkacz Marta, Puchałowicz Kamila, Safranow Krzysztof, Domanski Leszek, Pawlik Andrzej
Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Ir J Med Sci. 2018 Nov;187(4):1083-1087. doi: 10.1007/s11845-018-1767-4. Epub 2018 Mar 1.
Urokinase-type plasminogen activator receptor (uPAR) is found in a variety of cell types including monocytes, lymphocytes, macrophages, and endothelial cells and plays an important role in fibrinolysis and in the activation and chemotaxis of neutrophils and lymphocytes. In this study, we examined the correlation between uPAR plasma concentration and kidney allograft function.
This study enrolled 78 Caucasian deceased-donor renal transplant recipients.
Plasma concentrations of uPAR were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits.
We observed elevated with borderline significance (p = 0.095) uPAR plasma concentrations in patients with tubular atrophy. Plasma concentrations of uPAR showed strong statistically significant positive correlations with serum creatinine or urea and strong negative correlation with estimated glomerular filtration rate (eGFR). There was also a borderline positive correlation between uPAR plasma concentration and protein concentration in urine as well as the duration of hemodialysis.
The results of our study indicate that uPAR plasma concentrations in kidney allograft recipients are significantly negatively correlated with graft function and may be elevated in patients with tubular atrophy.
尿激酶型纤溶酶原激活物受体（uPAR）存在于多种细胞类型中，包括单核细胞、淋巴细胞、巨噬细胞和内皮细胞，在纤维蛋白溶解以及中性粒细胞和淋巴细胞的激活与趋化作用中发挥重要作用。在本研究中，我们检测了uPAR血浆浓度与肾移植功能之间的相关性。
本研究纳入了78名白种人尸体供肾肾移植受者。
使用市售酶联免疫吸附测定（ELISA）试剂盒测量uPAR的血浆浓度。
我们观察到肾小管萎缩患者的uPAR血浆浓度升高，具有临界显著性（p = 0.095）。uPAR的血浆浓度与血清肌酐或尿素呈强统计学显著正相关，与估计肾小球滤过率（eGFR）呈强负相关。uPAR血浆浓度与尿蛋白浓度以及血液透析持续时间之间也存在临界正相关。
我们的研究结果表明，肾移植受者的uPAR血浆浓度与移植肾功能显著负相关，并且在肾小管萎缩患者中可能升高。
