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名称有何含义:培养的红细胞是“天然的”吗?

What's in a name: are cultured red blood cells 'natural'?

作者信息

King Emma, Lyall Catherine

机构信息

NMAHP Research, University of Stirling, UK.

School of Social and Political Science, University of Edinburgh, UK.

出版信息

Sociol Health Illn. 2018 May;40(4):687-701. doi: 10.1111/1467-9566.12717. Epub 2018 Mar 2.

DOI:10.1111/1467-9566.12717
PMID:29498085
Abstract

The case of cultured red blood cells (RBCs) currently being grown in a laboratory for future use in human transfusion raises questions about the ontological status of such products of modern biotechnology. This paper presents results from a six-year ethnographic study involving interviews, focus groups and other forms of engagement with the scientific research team and other stakeholders, including public groups, which sought to understand respondents' reactions to cultured RBCs. These cells, derived from stem cell technology, have the potential to address the global shortage of donated blood. How these blood cells are situated within the spectrum of 'natural' to 'synthetic' will shape expectations and acceptance of this product, both within the scientific community and by wider publics: these blood cells are both novel and yet, at the same time, very familiar. Drawing on discussions related to classification and 'anchoring', we examine the contrasting discourses offered by our respondents on whether these blood cells are 'natural' or not and consider the impact that naming might have on both their future regulation and the eventual uptake of cultured RBCs by society.

摘要

目前正在实验室培养以供未来人类输血使用的红细胞(RBC)案例引发了关于这种现代生物技术产品本体论地位的问题。本文展示了一项为期六年的人种志研究结果,该研究涉及访谈、焦点小组以及与科研团队和其他利益相关者(包括公众群体)的其他形式的互动,旨在了解受访者对培养红细胞的反应。这些源自干细胞技术的细胞有潜力解决全球献血短缺问题。这些血细胞在“天然”到“合成”的光谱中的定位将塑造科学界和更广泛公众对该产品的期望和接受度:这些血细胞既新颖又同时非常熟悉。借助与分类和“锚定”相关的讨论,我们审视了受访者关于这些血细胞是否“天然”所提供的不同论述,并考虑命名可能对其未来监管以及社会最终采用培养红细胞产生的影响。

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What's in a name: are cultured red blood cells 'natural'?名称有何含义:培养的红细胞是“天然的”吗?
Sociol Health Illn. 2018 May;40(4):687-701. doi: 10.1111/1467-9566.12717. Epub 2018 Mar 2.
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Banking of pluripotent adult stem cells as an unlimited source for red blood cell production: potential applications for alloimmunized patients and rare blood challenges.成体多能干细胞库作为红细胞生成的无限来源:同种免疫患者和稀有血型挑战的潜在应用。
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Blood, meat, and upscaling tissue engineering: Promises, anticipated markets, and performativity in the biomedical and agri-food sectors.血液、肉类与规模化组织工程:生物医学和农业食品领域的前景、预期市场及性能表现
Biosocieties. 2018 Jun;13:368-388. doi: 10.1057/s41292-017-0072-1. Epub 2018 Jan 15.
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Nat Commun. 2020 Dec 8;11(1):6265. doi: 10.1038/s41467-020-20096-1.