Yasul Yavuz, Yılmaz Büşra, Şenel Ömer, Kurt Dursun, Akbulut Taner, Çalıkuşu Ayşen, Anadol Elvan, Yılmaz Canan
Bafra Vocational School, Ondokuz Mayıs University, 55400, Bafra, Samsun, Türkiye.
Faculty of Sport Sciences, Gazi University, Ankara, Türkiye.
Eur J Appl Physiol. 2025 Mar 18. doi: 10.1007/s00421-025-05756-8.
Coenzyme Q (Q) is a mitochondrial coenzyme that facilitates ATP production via oxidative phosphorylation. This study hypothesized that Q enhances mitochondrial efficiency and lactate threshold, while high-intensity interval training (HIIT) promotes metabolic adaptations, improving glucose utilization and buffering capacity for faster recovery after high-intensity exercise.
A randomized controlled trial was conducted using 24 male Sprague-Dawley rats (250.4 ± 6.1 g, 8 weeks old). The rats were allocated into four groups: control (C), coenzyme Q (CoQ), HIIT, and HIIT + Q. The Q administration involved a dosage of 10 mg/kg/day, given 30 min prior to the HIIT protocol. Lactate threshold, blood gas parameters, oximetry values, metabolite levels, and electrolyte status were analyzed utilizing the Radiometer 900 device. The blood samples were collected at the fifth and tenth minutes following the HIIT training trials.
The HIIT + Q group exhibited a significant reduction in lactate threshold (p < 0.01), maintaining values below average. Significant improvements in blood gas parameters, including pH, pO2, and pCO2, were observed in this group. Enhanced oxygen transport capacity was indicated by improved oximetry parameters (Hb, HCT, sO) and reduced COHb levels. Additionally, positive changes in HCO- and base values indicated reduced metabolic stress. Q supplementation also stabilized electrolytes, particularly K and Na.
The Q supplementation supported metabolic balance, improved oxygen transport, and stabilized acid-base levels during HIIT. It reduced lactate accumulation, enhanced glucose availability, and alleviated metabolic stress, thereby improving recovery efficiency and physiological adaptation.
辅酶Q（Q）是一种线粒体辅酶，通过氧化磷酸化促进三磷酸腺苷（ATP）的生成。本研究假设，辅酶Q可提高线粒体效率和乳酸阈值，而高强度间歇训练（HIIT）可促进代谢适应，改善葡萄糖利用和缓冲能力，从而在高强度运动后更快恢复。
使用24只雄性斯普拉格-道利大鼠（250.4±6.1克，8周龄）进行随机对照试验。将大鼠分为四组：对照组（C）、辅酶Q组（CoQ）、HIIT组和HIIT+Q组。辅酶Q的给药剂量为10毫克/千克/天，在HIIT方案前30分钟给予。使用Radiometer 900设备分析乳酸阈值、血气参数、血氧饱和度值、代谢物水平和电解质状态。在HIIT训练试验后的第五和第十分钟采集血样。
HIIT+Q组的乳酸阈值显著降低（p<0.01），维持在平均水平以下。该组的血气参数，包括pH值、氧分压（pO2）和二氧化碳分压（pCO2）有显著改善。血氧饱和度参数（血红蛋白（Hb）、血细胞比容（HCT）、血氧饱和度（sO））的改善和碳氧血红蛋白（COHb）水平的降低表明氧运输能力增强。此外，碳酸氢根离子（HCO-）和碱值的积极变化表明代谢应激降低。补充辅酶Q还使电解质，特别是钾（K）和钠（Na）稳定。
补充辅酶Q有助于在HIIT期间维持代谢平衡、改善氧运输和稳定酸碱水平。它减少了乳酸积累，提高了葡萄糖可用性，并减轻了代谢应激，从而提高了恢复效率和生理适应性。
