Wilentz J R, Sanborn T A, Haudenschild C C, Valeri C R, Ryan T J, Faxon D P
Circulation. 1987 Mar;75(3):636-42. doi: 10.1161/01.cir.75.3.636.
Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 X 10(6) platelets/1 cm vessel length) was observed at 30 min and remained active until 4 hr after angioplasty. Total accumulation over 24 hr was 56.4 +/- 4.7 X 10(6) platelets/1 cm length. Histologic dissection was directly related to the degree of platelet accumulation, with 64 +/- 15 X 10(6) platelets/1 cm in the group with marked dissection and 8.7 +/- 3.7 X 10(6) platelets/1 cm in the group with minimal dissection (p less than .05). Increasing angiographic dissection also resulted in a trend toward increased platelet accumulation, and angiographic change in luminal diameter showed a significant correlation with platelet accumulation. It is concluded that marked platelet accumulation occurs early after transluminal angioplasty and is related to the extent of dissection. Restenosis may result from a complex interaction of platelet accumulation, vascular damage, and blood flow.
由于血小板聚集可能是血管成形术后再狭窄的一个重要决定因素，因此在去内皮、高胆固醇血症兔动脉粥样硬化模型中评估了实验性血管成形术后51Cr标记的血小板聚集的时间进程。在血管成形术后30分钟观察到明显的血小板聚集（39.5±8.7×10(6)个血小板/1厘米血管长度），并且在血管成形术后4小时内一直保持活跃。24小时内的总聚集量为56.4±4.7×10(6)个血小板/1厘米长度。组织学剥离与血小板聚集程度直接相关，在明显剥离组为64±15×10(6)个血小板/1厘米，在最小剥离组为8.7±3.7×10(6)个血小板/1厘米（p<0.05）。血管造影剥离增加也导致血小板聚集有增加趋势，并且管腔直径的血管造影变化与血小板聚集呈显著相关。得出的结论是，经皮腔内血管成形术后早期会发生明显的血小板聚集，并且与剥离程度有关。再狭窄可能是血小板聚集、血管损伤和血流之间复杂相互作用的结果。
