从分子生物学角度看支架对冠状动脉内皮的影响：是否需要改进？
The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?
机构信息
Department of Cardiology, Pneumology, Angiology, and Internal Intensive Medicine, University Hospital Aachen, Aachen, Germany.
出版信息
J Cell Mol Med. 2019 Jan;23(1):39-46. doi: 10.1111/jcmm.13936. Epub 2018 Oct 23.
Abstract
Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of vascular endothelium. The damaged endothelium is intrinsically repaired by locally derived endothelial cells and by circulating endothelial progenitor cells from the blood, leading to re-population of the denuded regions within several weeks to months. However, the process of re-endothelialization is often incomplete or dysfunctional, promoting in-stent thrombosis and restenosis. The molecular and biomechanical mechanisms that influence the process of re-endothelialization in stented segments are incompletely understood. Once the endothelium is restored, endothelial function might still be impaired. Several strategies have been followed to improve endothelial function after coronary stenting. In this review, the effects of stenting on coronary endothelium are outlined and current and future strategies to improve endothelial function after stent deployment are discussed.
摘要
球囊血管成形术后的冠状动脉支架置入术是冠状动脉狭窄血运重建的金标准。然而，支架置入术和单纯经皮腔内冠状动脉血管成形术（PTCA）都会导致严重的血管内皮损伤。受损的内皮细胞通过局部来源的内皮细胞和来自血液的循环内皮祖细胞进行内在修复，导致在数周到数月内重新填充裸露区域。然而，再内皮化的过程往往是不完全或功能失调的，促进支架内血栓形成和再狭窄。影响支架段再内皮化过程的分子和生物力学机制尚不完全清楚。一旦内皮细胞得到恢复，内皮功能仍可能受损。已经采用了几种策略来改善冠状动脉支架置入术后的内皮功能。在这篇综述中，概述了支架置入术对冠状动脉内皮的影响，并讨论了目前和未来改善支架置入术后内皮功能的策略。
相似文献
1
The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?从分子生物学角度看支架对冠状动脉内皮的影响：是否需要改进？
J Cell Mol Med. 2019 Jan;23(1):39-46. doi: 10.1111/jcmm.13936. Epub 2018 Oct 23.
2
The effects of stenting on shear stress: relevance to endothelial injury and repair.支架对切应力的影响：与内皮损伤和修复的相关性。
Cardiovasc Res. 2013 Jul 15;99(2):269-75. doi: 10.1093/cvr/cvt090. Epub 2013 Apr 15.
3
Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy.血管损伤和支架置入后平滑肌细胞增殖和内皮再生的机制：治疗方法。
Circ J. 2011;75(6):1287-96. doi: 10.1253/circj.cj-11-0366. Epub 2011 Apr 29.
4
The forgotten player of in-stent restenosis: endothelial dysfunction.支架内再狭窄中被遗忘的因素：内皮功能障碍。
Int J Cardiol. 2008 Jun 6;126(3):443-4. doi: 10.1016/j.ijcard.2007.02.050. Epub 2007 Apr 26.
5
Coronary artery endothelial protection after local delivery of 17beta-estradiol during balloon angioplasty in a porcine model: a potential new pharmacologic approach to improve endothelial function.猪模型中球囊血管成形术期间局部递送17β-雌二醇后的冠状动脉内皮保护：一种改善内皮功能的潜在新药理学方法。
J Am Coll Cardiol. 2001 Nov 1;38(5):1570-6. doi: 10.1016/s0735-1097(01)01552-2.
6
Circulating endothelial progenitor cell levels and function in patients who experienced late coronary stent thrombosis.经历晚期冠状动脉支架血栓形成的患者的循环内皮祖细胞水平和功能。
Eur Heart J. 2010 Nov;31(21):2625-32. doi: 10.1093/eurheartj/ehq184. Epub 2010 Jun 11.
7
Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events and restenosis in patients undergoing coronary stent implantation: a prospective study.冠状动脉支架植入患者非侵入性测定的内皮功能障碍对长期心血管事件和再狭窄的预测价值：一项前瞻性研究。
Coron Artery Dis. 2008 Aug;19(5):337-43. doi: 10.1097/MCA.0b013e328301ba8e.
8
The Genous™ endothelial progenitor cell capture stent accelerates stent re-endothelialization but does not affect intimal hyperplasia in porcine coronary arteries.Genous™ 内皮祖细胞捕获支架可加速支架再内皮化，但不影响猪冠状动脉内膜增生。
Catheter Cardiovasc Interv. 2012 Feb 1;79(2):231-42. doi: 10.1002/ccd.22928. Epub 2011 Aug 10.
9
Use of endothelial progenitor capture cell stent during percutaneous treatment of coronary bifurcations: a prospective angiographic registry.内皮祖细胞捕获细胞支架在经皮冠状动脉分叉病变治疗中的应用：一项前瞻性血管造影登记研究。
Crit Pathw Cardiol. 2011 Dec;10(4):189-92. doi: 10.1097/HPC.0b013e318233d57f.
10
引用本文的文献
1
The mechanisms and applications of endothelial progenitor cell therapy in the treatment of intracranial aneurysm.内皮祖细胞疗法在颅内动脉瘤治疗中的机制及应用
J Transl Med. 2025 Mar 27;23(1):377. doi: 10.1186/s12967-025-06401-w.
2
Implantable Biosensors for Vascular Diseases: Directions for the Next Generation of Active Diagnostic and Therapeutic Medical Device Technologies.用于血管疾病的可植入生物传感器：下一代主动诊断和治疗医疗设备技术的发展方向。
Biosensors (Basel). 2025 Feb 25;15(3):147. doi: 10.3390/bios15030147.
3
Endothelial and smooth muscle cell interaction with hydrothermally treated titanium surfaces.内皮细胞和平滑肌细胞与水热处理钛表面的相互作用。
In Vitro Model. 2024 Jul 19;3(2-3):109-123. doi: 10.1007/s44164-024-00073-4. eCollection 2024 Jun.
4
Functional Mechanical Behavior and Biocompatible Characteristics of Graphene-Coated Cardiovascular Stents.石墨烯涂层心血管支架的功能力学行为及生物相容性特征
Int J Mol Sci. 2024 Dec 12;25(24):13345. doi: 10.3390/ijms252413345.
5
Manufacturing, Processing, and Characterization of Self-Expanding Metallic Stents: A Comprehensive Review.自膨式金属支架的制造、加工与表征：综述
Bioengineering (Basel). 2024 Sep 29;11(10):983. doi: 10.3390/bioengineering11100983.
6
Exploring the potential of laser-textured metal alloys: Fine-tuning vascular cells responses through and analysis.探索激光纹理金属合金的潜力：通过[此处原文缺失相关内容]和分析微调血管细胞反应。
Bioact Mater. 2024 Sep 23;43:181-194. doi: 10.1016/j.bioactmat.2024.09.019. eCollection 2025 Jan.
7
Silencing of mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission.通过抑制STAT3/DRP1介导的线粒体分裂，[基因名称]的沉默减轻了血管平滑肌细胞的增殖和迁移以及血管内膜增生。 （注：原文中Silencing of 后面缺少具体基因名称）
Acta Biochim Biophys Sin (Shanghai). 2024 Sep 11;57(4):633-645. doi: 10.3724/abbs.2024154.
8
Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides.使用CD31结构域1和2模拟肽为血管内支架披上内皮外衣。
JVS Vasc Sci. 2024 Jul 23;5:100213. doi: 10.1016/j.jvssci.2024.100213. eCollection 2024.
9
Pentagalloyl glucose induces anti-inflammatory macrophage polarization - suppressing macrophage mediated vascular cell dysfunction and TGF-β secretion.没食子酰葡萄糖诱导抗炎型巨噬细胞极化——抑制巨噬细胞介导的血管细胞功能障碍和 TGF-β 分泌。
Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320241276894. doi: 10.1177/03946320241276894.
10
Endothelial Progenitor Cells: A Review of Molecular Mechanisms in the Pathogenesis and Endovascular Treatment of Intracranial Aneurysms.内皮祖细胞：颅内动脉瘤发病机制和血管内治疗中的分子机制综述。
Neuromolecular Med. 2024 Jun 17;26(1):25. doi: 10.1007/s12017-024-08791-4.
本文引用的文献
1
Targeting In-Stent-Stenosis with RGD- and CXCL1-Coated Mini-Stents in Mice.在小鼠中使用RGD和CXCL1涂层的微型支架靶向治疗支架内狭窄
PLoS One. 2016 May 18;11(5):e0155829. doi: 10.1371/journal.pone.0155829. eCollection 2016.
2
3
Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease.依维莫司洗脱生物可吸收支架治疗冠状动脉疾病。
N Engl J Med. 2015 Nov 12;373(20):1905-15. doi: 10.1056/NEJMoa1509038. Epub 2015 Oct 12.
4
Effect of a Novel Stent on Re-Endothelialization, Platelet Adhesion, and Neointimal Formation.一种新型支架对再内皮化、血小板黏附及新生内膜形成的影响。
J Atheroscler Thromb. 2016;23(1):67-80. doi: 10.5551/jat.31062. Epub 2015 Sep 3.
5
Thrombogenicity and early vascular healing response in metallic biodegradable polymer-based and fully bioabsorbable drug-eluting stents.基于金属可生物降解聚合物和完全可生物吸收的药物洗脱支架的血栓形成性和早期血管愈合反应
Circ Cardiovasc Interv. 2015 Jun;8(6):e002427. doi: 10.1161/CIRCINTERVENTIONS.115.002427.
6
A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial.生物可吸收依维莫司洗脱支架与金属依维莫司洗脱支架治疗初发原生冠状动脉病变所致缺血性心脏病的比较（ABSORB II）：一项随机对照临床试验的临床和操作次要终点 1 年中期分析。
Lancet. 2015 Jan 3;385(9962):43-54. doi: 10.1016/S0140-6736(14)61455-0. Epub 2014 Sep 14.
7
Percutaneous coronary intervention with everolimus-eluting bioresorbable vascular scaffolds in routine clinical practice: early and midterm outcomes from the European multicentre GHOST-EU registry.依维莫司洗脱生物可吸收血管支架在常规临床实践中的经皮冠状动脉介入治疗：欧洲多中心GHOST-EU注册研究的早期和中期结果
EuroIntervention. 2015 Feb;10(10):1144-53. doi: 10.4244/EIJY14M07_11.
8
Lumen gain and restoration of pulsatility after implantation of a bioresorbable vascular scaffold in porcine coronary arteries.生物可吸收血管支架植入猪冠状动脉后管腔获得和搏动恢复。
JACC Cardiovasc Interv. 2014 Jun;7(6):688-95. doi: 10.1016/j.jcin.2013.11.024. Epub 2014 May 14.
9
Next-generation DES: the COMBO dual therapy stent with Genous endothelial progenitor capturing technology and an abluminal sirolimus matrix.新一代药物洗脱支架：COMBO 双重治疗支架，具有 Genous 内皮祖细胞捕获技术和外膜西罗莫司基质。
Expert Rev Med Devices. 2014 Mar;11(2):121-35. doi: 10.1586/17434440.2014.882046. Epub 2014 Feb 3.
10
Dynamics of vessel wall changes following the implantation of the absorb everolimus-eluting bioresorbable vascular scaffold: a multi-imaging modality study at 6, 12, 24 and 36 months.依维莫司洗脱可吸收生物可降解血管支架植入后血管壁变化的动态研究：一项在6个月、12个月、24个月和36个月时进行的多成像模态研究
EuroIntervention. 2014 Mar 20;9(11):1271-84. doi: 10.4244/EIJV9I11A217.
Zotero 插件