The Department of Microbiology and Immunology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
Immunol Cell Biol. 2018 May;96(5):453-462. doi: 10.1111/imcb.12030. Epub 2018 Mar 24.
Altered B-cell homeostasis underlies a wide range of pathologies, from cancers to autoimmunity and immunodeficiency. The molecular safeguards against those disorders, which also allow effective immune responses, are therefore particularly critical. Here, we review recent findings detailing the fine control of B-cell homeostasis, during B-cell development, maturation in the periphery and during activation and differentiation into antibody-producing cells.
异常的 B 细胞稳态是多种病理的基础，包括癌症、自身免疫和免疫缺陷。因此，对抗这些疾病的分子保护机制对于有效免疫反应尤为关键。在此，我们综述了近期关于 B 细胞在发育、外周成熟以及在激活和分化为产生抗体的细胞过程中稳态精细调控的研究发现。
