错失目标：PRDM9 依赖性甲基化是减数分裂 DSB 靶向所必需的。
Missing the Mark: PRDM9-Dependent Methylation Is Required for Meiotic DSB Targeting.
机构信息
Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA; Program in Genetics and Epigenetics, MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Science Park, Smithville, TX 78957, USA.
Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA.
出版信息
Mol Cell. 2018 Mar 1;69(5):725-727. doi: 10.1016/j.molcel.2018.02.021.
PRDM9 determines the localization of meiotic recombination hotspots, which are associated with histone H3 methylation. It is not known whether PRDM9's methyltransferase activity is required or how some PRDM9 alleles can dominate the distribution of hotspots over other alleles. Diagouraga, Clément, and colleagues (2018) show that methyltransferase activity is required for hotspot localization and that this activity is additive in combination, suggesting that the dominance of particular alleles is simply proportional to the frequency of targeted sites.
PRDM9 决定着减数分裂重组热点的位置，这些热点与组蛋白 H3 甲基化有关。目前尚不清楚 PRDM9 的甲基转移酶活性是否必需，也不知道某些 PRDM9 等位基因如何能够支配热点相对于其他等位基因的分布。Diagouraga、Clément 及其同事（2018 年）表明，甲基转移酶活性是热点定位所必需的，并且这种活性在组合中具有加性，这表明特定等位基因的优势仅仅与其靶向位点的频率成正比。
Zotero 插件