谁在捍卫干细胞的堡垒？
Who Defends the Stem Cell's Citadel?
机构信息
Innate Immunity Unit, Institut Pasteur, 75724, Paris, France; INSERM U1223, Paris, France.
INSERM, U1052, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France.
出版信息
Cell Stem Cell. 2018 Mar 1;22(3):287-289. doi: 10.1016/j.stem.2018.02.007.
PMID:29499145
Abstract
Recently in Cell, Wu et al. (2018) demonstrated that intrinsic expression of a subset of interferon stimulated genes confers resistance to viral infections in stem cells both in vitro and in vivo, while differentiated cells lose this intrinsic gatekeeper expression pattern in favor of inducible interferon responses.
摘要
最近，在《细胞》杂志上，Wu 等人（2018 年）表明，一组干扰素刺激基因的内在表达赋予了干细胞在体外和体内抵抗病毒感染的能力，而分化细胞则失去了这种内在的“守门员”表达模式，转而支持诱导型干扰素反应。
Zotero 插件