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固有干扰素程序可保护干细胞免受病毒感染。

An Intrinsic Interferon Program Protects Stem Cells from Viral Infection.

机构信息

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), DKFZ, 69120 Heidelberg, Germany.

出版信息

Dev Cell. 2018 Feb 5;44(3):279-280. doi: 10.1016/j.devcel.2018.01.013.

DOI:10.1016/j.devcel.2018.01.013
PMID:29408233
Abstract

Specific protection mechanisms are required to safeguard stem cell integrity. In a recent issue of Cell, Wu et al. (2018) show that stem cells are equipped with high intrinsic expression of interferon-stimulated genes (ISGs) but remain refractory to acute interferon signaling. This protects stem cells from viral infection.

摘要

需要特定的保护机制来维护干细胞的完整性。在最近一期的《细胞》杂志上，Wu 等人（2018 年）表明，干细胞具有高表达干扰素刺激基因（ISGs）的内在特性，但对急性干扰素信号仍具有抗性。这可以保护干细胞免受病毒感染。

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