Nakao K, Katsuura G, Morii N, Itoh H, Shiono S, Yamada T, Sugawara A, Sakamoto M, Saito Y, Eigyo M
Eur J Pharmacol. 1986 Nov 19;131(2-3):171-7. doi: 10.1016/0014-2999(86)90570-4.
The effects of intracerebroventricular injection of atrial natriuretic polypeptide (ANP) and angiotensin II (AII) on the concentration of dopamine, noradrenaline, serotonin and their primary metabolites in the rat brain were studied using high performance liquid chromatography with electrochemical detection. ANP (2 and 5 micrograms) decreased the level of dopamine and its metabolite in the septum and hypothalamus. In contrast, AII (100 ng) increased their levels in these brain regions. The simultaneous administration of ANP (5 micrograms) with AII (100 ng) resulted in a marked reduction of the AII-induced increase of dopamine and its metabolite. No significant changes were observed in the concentrations of noradrenaline and serotonin throughout the brain. These results suggest that the central action of ANP is mediated in part via the dopaminergic system.
采用高效液相色谱-电化学检测法，研究了脑室内注射心房利钠多肽（ANP）和血管紧张素II（AII）对大鼠脑内多巴胺、去甲肾上腺素、5-羟色胺及其主要代谢产物浓度的影响。ANP（2微克和5微克）降低了隔区和下丘脑内多巴胺及其代谢产物的水平。相反，AII（100纳克）提高了这些脑区中它们的水平。ANP（5微克）与AII（100纳克）同时给药导致AII诱导的多巴胺及其代谢产物增加明显减少。全脑去甲肾上腺素和5-羟色胺的浓度未观察到显著变化。这些结果表明，ANP的中枢作用部分是通过多巴胺能系统介导的。
