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[再喂养综合征:病理生理学、危险因素、预防及治疗]

[Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].

作者信息

Wirth R, Diekmann R, Janssen G, Fleiter O, Fricke L, Kreilkamp A, Modreker M K, Marburger C, Nels S, Pourhassan M, Schaefer R, Willschrei H-P, Volkert D

机构信息

Klinik für Altersmedizin und Frührehabilitation, Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.

Lehrstuhl für Geriatrie, Ruhr-Universität Bochum, Bochum, Deutschland.

出版信息

Internist (Berl). 2018 Apr;59(4):326-333. doi: 10.1007/s00108-018-0399-0.

DOI:10.1007/s00108-018-0399-0
PMID:29500574
Abstract

Refeeding syndrome is a life-threatening complication that may occur after initiation of nutritional therapy in malnourished patients, as well as after periods of fasting and hunger. Refeeding syndrome can be effectively prevented and treated if its risk factors and pathophysiology are known. The initial measurement of thiamine level and serum electrolytes, including phosphate and magnesium, their supplementation if necessary, and a slow increase in nutritional intake along with close monitoring of serum electrolytes play an important role. Since refeeding syndrome is not well known and the symptoms can be extremely heterogeneous, this complication is poorly recognized, especially against the background of severe disease and multimorbidity. This overview aims to summarize the current knowledge and increase awareness about refeeding syndrome.

摘要

再喂养综合征是一种危及生命的并发症,可能发生在营养不良患者开始营养治疗后,以及禁食和饥饿一段时间后。如果了解再喂养综合征的危险因素和病理生理学,就可以有效地预防和治疗该综合征。最初测量硫胺素水平和血清电解质,包括磷酸盐和镁,必要时进行补充,以及缓慢增加营养摄入量并密切监测血清电解质,这些都起着重要作用。由于再喂养综合征并不广为人知,且症状可能极为多样,这种并发症很难被识别,尤其是在严重疾病和多种疾病并存的背景下。本综述旨在总结当前关于再喂养综合征的知识,并提高人们对其的认识。

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1
[Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].[再喂养综合征:病理生理学、危险因素、预防及治疗]
Internist (Berl). 2018 Apr;59(4):326-333. doi: 10.1007/s00108-018-0399-0.
2
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引用本文的文献

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Incidence and Risk Factors of Refeeding Syndrome in Preterm Infants.早产儿喂养综合征的发生率及危险因素。
Nutrients. 2024 Aug 3;16(15):2557. doi: 10.3390/nu16152557.
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One Page in the History of Starvation and Refeeding.饥饿与再喂养历史中的一页。
Rambam Maimonides Med J. 2024 Apr 28;15(2):e0010. doi: 10.5041/RMMJ.10524.
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Hypophosphatemia after Start of Medical Nutrition Therapy Indicates Early Refeeding Syndrome and Increased Electrolyte Requirements in Critically Ill Patients but Has No Impact on Short-Term Survival.

本文引用的文献

1
Prevalence of Risk Factors for the Refeeding Syndrome in Older Hospitalized Patients.老年住院患者再喂养综合征风险因素的流行情况。
J Nutr Health Aging. 2018;22(3):321-327. doi: 10.1007/s12603-017-0917-0.
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Risk factors of refeeding syndrome in malnourished older hospitalized patients.营养不良的老年住院患者再喂养综合征的风险因素。
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Revisiting the refeeding syndrome: Results of a systematic review.重新审视再喂养综合征:系统评价结果
开始医学营养治疗后出现低磷血症表明危重症患者存在早期再喂养综合征和增加电解质需求,但对短期生存率无影响。
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Refeeding Syndrome in Older Hospitalized Patients: Incidence, Management, and Outcomes.老年住院患者的再喂养综合征:发病率、管理及结局
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SIRT3-mediated mitochondrial autophagy in refeeding syndrome-related myocardial injury in sepsis rats.SIRT3介导的脓毒症大鼠再喂养综合征相关心肌损伤中的线粒体自噬
Ann Transl Med. 2022 Feb;10(4):211. doi: 10.21037/atm-22-222.
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[Geriatric intensive care : Consensus paper of DGIIN, DIVI, DGAI, DGGG, ÖGGG, ÖGIAIN, DGP, DGEM, DGD, DGNI, DGIM, DGKliPha and DGG].[老年重症监护:德国重症与急诊医学跨学科协会(DGIIN)、德国重症医学与急诊医学学会(DIVI)、德国麻醉医师协会(DGAI)、德国老年医学协会(DGGG)、奥地利老年医学协会(ÖGGG)、奥地利重症与急诊医学跨学科协会(ÖGIAIN)、德国病理学会(DGP)、德国急诊医学协会(DGEM)、德国重症监护与急诊医学学会(DGD)、德国神经重症监护与急诊医学协会(DGNI)、德国重症医学与围手术期医学协会(DGIM)、德国重症监护与疼痛医学跨学科协会(DGKliPha)和德国老年医学协会(DGG)的共识文件]
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Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial.限制与继续标准热量摄入在危重症成人再喂养综合征管理中的比较:一项随机、平行分组、多中心、单盲对照试验。
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Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.长期使用质子泵抑制剂引起的低镁血症
Gastroenterol Res Pract. 2015;2015:951768. doi: 10.1155/2015/951768. Epub 2015 May 4.
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Refeeding syndrome: problems with definition and management.再喂养综合征:定义与管理方面的问题。
Nutrition. 2014 Nov-Dec;30(11-12):1448-55. doi: 10.1016/j.nut.2014.03.026. Epub 2014 Apr 18.
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