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[再喂养综合征:病理生理学、危险因素、预防及治疗]

[Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].

作者信息

Wirth R, Diekmann R, Janssen G, Fleiter O, Fricke L, Kreilkamp A, Modreker M K, Marburger C, Nels S, Pourhassan M, Schaefer R, Willschrei H-P, Volkert D

机构信息

Klinik für Altersmedizin und Frührehabilitation, Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.

Lehrstuhl für Geriatrie, Ruhr-Universität Bochum, Bochum, Deutschland.

出版信息

Internist (Berl). 2018 Apr;59(4):326-333. doi: 10.1007/s00108-018-0399-0.

Abstract

Refeeding syndrome is a life-threatening complication that may occur after initiation of nutritional therapy in malnourished patients, as well as after periods of fasting and hunger. Refeeding syndrome can be effectively prevented and treated if its risk factors and pathophysiology are known. The initial measurement of thiamine level and serum electrolytes, including phosphate and magnesium, their supplementation if necessary, and a slow increase in nutritional intake along with close monitoring of serum electrolytes play an important role. Since refeeding syndrome is not well known and the symptoms can be extremely heterogeneous, this complication is poorly recognized, especially against the background of severe disease and multimorbidity. This overview aims to summarize the current knowledge and increase awareness about refeeding syndrome.

摘要

再喂养综合征是一种危及生命的并发症,可能发生在营养不良患者开始营养治疗后,以及禁食和饥饿一段时间后。如果了解再喂养综合征的危险因素和病理生理学,就可以有效地预防和治疗该综合征。最初测量硫胺素水平和血清电解质,包括磷酸盐和镁,必要时进行补充,以及缓慢增加营养摄入量并密切监测血清电解质,这些都起着重要作用。由于再喂养综合征并不广为人知,且症状可能极为多样,这种并发症很难被识别,尤其是在严重疾病和多种疾病并存的背景下。本综述旨在总结当前关于再喂养综合征的知识,并提高人们对其的认识。

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