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[内耳疾病和贝尔麻痹中的淋巴细胞亚群及HLA - DR检测]

[Lymphocyte subpopulations and HLA-DR determinations in diseases of the inner ear and Bell's palsy].

作者信息

Bumm P, Schlimok G

出版信息

HNO. 1986 Dec;34(12):525-7.

PMID:2950069
Abstract

Thymus lymphocytes-subpopulations (T-helper T4 and T-suppressorcells T8) were determined in inner ear diseases (e.g. sudden hearing loss, neuronitis vestibularis, Morbus Menière, Bell's Palsy) by specific monoclonal antibodies. T-cell subset ratio (T4/T8) was elevated (less than 3) in about 50% of all patients. DR-typifying was performed because of the well-known control of the immunoregulation through the class II HLA-DR antigens. There was a relative risk of 5.2 in peripheral vestibular lesion (neuronitis vestibularis). The relative risk of autoimmune diseases is found at this level.

摘要

通过特异性单克隆抗体对内耳疾病(如突发性听力损失、前庭神经炎、梅尼埃病、贝尔麻痹)中的胸腺淋巴细胞亚群(辅助性T4细胞和抑制性T8细胞)进行了测定。在所有患者中,约50%的T细胞亚群比例(T4/T8)升高(小于3)。由于已知通过II类HLA-DR抗原对免疫调节进行控制,因此进行了DR分型。外周前庭病变(前庭神经炎)的相对风险为5.2。在这个水平发现了自身免疫性疾病的相对风险。

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