TU Dresden, Faculty of Medicine Carl Gustav Carus, Anesthesiology and Intensive Care Medicine, Clini, Germany.
TU Dresden, Faculty of Medicine Carl Gustav Carus, Department of Medical Physics and Biomedical Engi, Germany.
J Biomed Opt. 2018 Mar;23(7):1-13. doi: 10.1117/1.JBO.23.7.071207.
The common way to diagnose hard and soft tissue irregularities in the oral cavity is initially the visual inspection by an experienced dentist followed by further medical examinations, such as radiological imaging and/or histopathological investigation. For the diagnosis of oral hard and soft tissues, the detection of early transformations is mostly hampered by poor visual access, low specificity of the diagnosis techniques, and/or limited feasibility of frequent screenings. Therefore, optical noninvasive diagnosis of oral tissue is promising to improve the accuracy of oral screening. Considering this demand, a rigid handheld endoscopic scanner was developed for optical coherence tomography (OCT). The novelty is the usage of a commercially near-infrared endoscope with fitting optics in combination with an established spectral-domain OCT system of our workgroup. By reaching a high spatial resolution, in vivo images of anterior and especially posterior dental and mucosal tissues were obtained from the oral cavity of two volunteers. The convincing image quality of the endoscopic OCT device is particularly obvious for the imaging of different regions of the human soft palate with highly scattering fibrous layer and capillary network within the lamina propria.
诊断口腔软硬组织不规则的常用方法最初是由经验丰富的牙医进行目视检查，然后再进行进一步的医学检查，如影像学检查和/或组织病理学检查。为了诊断口腔硬组织和软组织，早期病变的检测主要受到视觉通道不佳、诊断技术特异性低和/或频繁筛查的可行性有限的阻碍。因此，光学非侵入性诊断口腔组织有望提高口腔筛查的准确性。考虑到这一需求，我们开发了一种用于光学相干断层扫描（OCT）的刚性手持内窥镜扫描仪。新颖之处在于使用商业近红外内窥镜和合适的光学元件，结合我们工作组的已建立的光谱域 OCT 系统。通过达到高空间分辨率，从两名志愿者的口腔中获得了前牙和后牙特别是后牙以及口腔黏膜组织的活体图像。内窥镜 OCT 设备的图像质量令人信服，对于具有高度散射纤维层和固有层内毛细血管网络的人类软腭的不同区域的成像尤其明显。
