英国生物银行队列中精神分裂症的多基因风险与出生季节
Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort.
作者信息
Escott-Price Valentina, Smith Daniel J, Kendall Kimberley, Ward Joey, Kirov George, Owen Michael J, Walters James, O'Donovan Michael C
机构信息
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
出版信息
Psychol Med. 2019 Nov;49(15):2499-2504. doi: 10.1017/S0033291718000454. Epub 2018 Mar 4.
BACKGROUND
There is strong evidence that people born in winter and in spring have a small increased risk of schizophrenia. As this 'season of birth' effect underpins some of the most influential hypotheses concerning potentially modifiable risk exposures, it is important to exclude other possible explanations for the phenomenon.
METHODS
Here we sought to determine whether the season of birth effect reflects gene-environment confounding rather than a pathogenic process indexing environmental exposure. We directly measured, in 136 538 participants from the UK Biobank (UKBB), the burdens of common schizophrenia risk alleles and of copy number variants known to increase the risk for the disorder, and tested whether these were correlated with a season of birth.
RESULTS
Neither genetic measure was associated with season or month of birth within the UKBB sample.
CONCLUSIONS
As our study was highly powered to detect small effects, we conclude that the season of birth effect in schizophrenia reflects a true pathogenic effect of environmental exposure.
背景
有强有力的证据表明，在冬季和春季出生的人患精神分裂症的风险略有增加。由于这种“出生季节”效应支撑着一些关于潜在可改变风险暴露的最具影响力的假说，因此排除该现象的其他可能解释很重要。
方法
在此，我们试图确定出生季节效应是否反映了基因 - 环境混杂，而非指示环境暴露的致病过程。我们在英国生物银行（UKBB）的136538名参与者中，直接测量了常见精神分裂症风险等位基因的负担以及已知会增加该疾病风险的拷贝数变异的负担，并测试了这些是否与出生季节相关。
结果
在UKBB样本中，这两种遗传指标均与出生季节或月份无关。
结论
由于我们的研究有很强的能力检测出微小效应，我们得出结论，精神分裂症中的出生季节效应反映了环境暴露的真实致病效应。
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