Kou Wei, Li Xuelei, Yao Hongbing, Wei Ping
Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Int J Pediatr Otorhinolaryngol. 2018 Apr;107:131-134. doi: 10.1016/j.ijporl.2018.02.001. Epub 2018 Feb 5.
Allergic rhinitis (AR) and asthma often occur concomitantly and are the two most common inflammatory conditions of the airways in children. Large-scale studies investigating the comorbidity of asthma and AR in children are rare. So, we performed a meta-analysis to describe the comorbidity rate of asthma and AR in Chinese children.
We retrieved related studies from Pubmed, Science, Springer, Elsevier, Embase, BMJ, and four Chinese biomedical databases, including Wanfang Data, VIP, CBM, and CNKI. From these individual studies, the comorbidity rate of asthma and AR in Chinese children was extracted and pooled to generate summary effect estimates in R version 3.2.3.
The meta-analysis included 25 cross-sectional studies. The results indicated that in China, the incidence of asthma in children with AR is 35.01% (95% CI: 32.32%-37.70%) and the incidence of AR in children with asthma is 54.93% (95% CI: 53.05%-56.80%).
The comorbidity of AR and asthma is high in Chinese children. Statistically, the prevalence of AR was higher in children with asthma, as opposed to the prevalence of asthma in children with AR. The comorbidity rate of AR and asthma signifies the importance of improving the recognition and treatment under both conditions by respiratory physicians and otolaryngologists.
变应性鼻炎（AR）和哮喘常同时发生，是儿童气道最常见的两种炎症性疾病。关于儿童哮喘与AR共病情况的大规模研究较少。因此，我们进行了一项荟萃分析，以描述中国儿童哮喘与AR的共病率。
我们从PubMed、Science、Springer、Elsevier、Embase、BMJ以及四个中国生物医学数据库（万方数据、维普、中国生物医学文献数据库和中国知网）中检索相关研究。从这些个体研究中，提取并汇总中国儿童哮喘与AR的共病率，在R 3.2.3版本中生成汇总效应估计值。
该荟萃分析纳入了25项横断面研究。结果表明，在中国，AR患儿中哮喘的发病率为35.01%（95%CI：32.32%-37.70%），哮喘患儿中AR的发病率为54.93%（95%CI：53.05%-56.80%）。
中国儿童中AR与哮喘的共病率较高。从统计学角度看，哮喘患儿中AR的患病率较高，与AR患儿中哮喘的患病率情况相反。AR与哮喘的共病率表明呼吸内科医生和耳鼻喉科医生提高对这两种疾病的认识和治疗的重要性。
