Division of Cardiac Surgery, London Health Sciences Centre, Western University, London, Ontario, Canada.
Division of Cardiac Surgery, London Health Sciences Centre, Western University, London, Ontario, Canada.
Ann Thorac Surg. 2018 Jul;106(1):e19-e20. doi: 10.1016/j.athoracsur.2018.01.074. Epub 2018 Mar 1.
Cardiac ochronosis is a rare complication of alkaptonuria, a disorder of tyrosine metabolism characterized by a triad of dark urine, pigmentation of tissues, and ochronotic arthropathies. When present, cardiac ochronosis generally affects the aortic valve, resulting in aortic stenosis. More rarely, it may affect the mitral valve and the coronary arteries. This report describes the case of a 67-year-old woman with a history of alkaptonuria with severe ochronosis of the coronary arteries and mitral valve who required coronary artery bypass and mitral valve replacement.
心脏褐黄病是一种罕见的疾病，是酪氨酸代谢紊乱的一种表现，其特征为深色尿液、组织色素沉着和褐黄病性关节病三联征。当发生心脏褐黄病时，通常会影响主动脉瓣，导致主动脉瓣狭窄。更罕见的情况下，它可能会影响二尖瓣和冠状动脉。本报告描述了一例 67 岁女性的病例，该女性患有 alkaptonuria，其冠状动脉和二尖瓣严重褐黄病，需要进行冠状动脉旁路移植和二尖瓣置换。
