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[The role of the glutamatergic system in pathophysiology and pharmacotherapy for depression: preclinical and clinical data].[谷氨酸能系统在抑郁症病理生理学及药物治疗中的作用：临床前及临床数据]
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1
Investigational drugs in recent clinical trials for treatment-resistant depression.近期治疗难治性抑郁症临床试验中的研究性药物。
Expert Rev Neurother. 2017 Jun;17(6):593-609. doi: 10.1080/14737175.2017.1283217. Epub 2017 Jan 29.
2
Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders.氯胺酮：将机制性发现转化为用于治疗情绪障碍的新一代谷氨酸调节剂。
Mol Psychiatry. 2017 Mar;22(3):324-327. doi: 10.1038/mp.2016.249. Epub 2017 Jan 10.
3
The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant.瑞帕斯汀（原名GLYX-13）的研发；一种速效长效抗抑郁药。
Curr Neuropharmacol. 2017;15(1):47-56. doi: 10.2174/1570159x14666160321122703.
4
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.R-氯胺酮：一种起效迅速且作用持久的抗抑郁药，无拟精神病性副作用。
Transl Psychiatry. 2015 Sep 1;5(9):e632. doi: 10.1038/tp.2015.136.
5
Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test.N-甲基-D-天冬氨酸受体拮抗剂在丁苯那嗪抗抑郁药试验中的作用：与悬尾试验的比较
Acta Neuropsychiatr. 2015 Aug;27(4):228-34. doi: 10.1017/neu.2015.14. Epub 2015 Apr 10.
6
Glutamate-based antidepressants: 20 years on.基于谷氨酸的抗抑郁药：20 年的发展历程。
Trends Pharmacol Sci. 2009 Nov;30(11):563-9. doi: 10.1016/j.tips.2009.09.002.
7
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.一种创新设计，用于确立NR2B亚基选择性N-甲基-D-天冬氨酸拮抗剂CP-101,606对难治性重度抑郁症患者抗抑郁作用的概念验证。
J Clin Psychopharmacol. 2008 Dec;28(6):631-7. doi: 10.1097/JCP.0b013e31818a6cea.
8
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.一项关于N-甲基-D-天冬氨酸拮抗剂治疗难治性重度抑郁症的随机试验。
Arch Gen Psychiatry. 2006 Aug;63(8):856-64. doi: 10.1001/archpsyc.63.8.856.
9
Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity.S-氯胺酮和R-氯胺酮在代谢能力正常和降低的健康志愿者中的药代动力学及非镇痛作用。
Eur J Clin Pharmacol. 2002 Feb;57(12):869-75. doi: 10.1007/s002280100353.
10
Antidepressant effects of ketamine in depressed patients.氯胺酮对抑郁症患者的抗抑郁作用。
Biol Psychiatry. 2000 Feb 15;47(4):351-4. doi: 10.1016/s0006-3223(99)00230-9.

The development of glutamate-based antidepressants is taking longer than expected.

作者信息

Garay Ricardo, Zarate Carlos A, Cavero Icilio, Kim Yong-Ku, Charpeaud Thomas, Skolnick Phil

机构信息

Department of Pharmacology and Therapeutics, Craven, Villemoisson-sur-Orge, France; CNRS, National Centre of Scientific Research, Paris, France.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

出版信息

Drug Discov Today. 2018 Oct;23(10):1689-1692. doi: 10.1016/j.drudis.2018.02.006. Epub 2018 Mar 1.

DOI:10.1016/j.drudis.2018.02.006
PMID:29501913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6211562/
Abstract
摘要