手术后坏疽性脓皮病的延迟诊断：一项多中心病例系列研究及文献综述
Delayed diagnosis of post-surgical pyoderma gangrenosum: A multicenter case series and review of literature.
作者信息
Almukhtar Rawaa, Armenta Andrew M, Martin Julie, Goodwin Brandon P, Vincent Bethany, Lee Brain, Dacso Mara M
机构信息
Department of Dermatology, Louisiana State University, New Orleans, LA, USA.
Department of Dermatology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Int J Surg Case Rep. 2018;44:152-156. doi: 10.1016/j.ijscr.2018.02.026. Epub 2018 Feb 19.
INTRODUCTION
Pyoderma gangrenosum is a chronic neutrophilic dermatosis which can occur following trauma or surgery and can mimic infection. Surgical intervention can lead to progression of disease.
PRESENTATION OF CASES
This case series describes 3 cases of post-surgical pyoderma gangrenosum with delayed diagnosis from two large medical centers.
DISCUSSION
Epidemiology, pathogenesis, clinical and histopathologic presentation, and management of post-surgical pyoderma gangrenosum are discussed with a review of the literature.
CONCLUSION
Post-surgical pyoderma gangrenosum (PSPG) can mimic ulcerative disorders including bacterial infection. The diagnosis should be suspected in post-operative wounds with negative bacterial cultures which progress despite broad-spectrum antibiotics and surgical debridement. Recognizing the clinical features of PSPG is fundamental to prevent severe destruction and deformity.
引言
坏疽性脓皮病是一种慢性嗜中性皮病，可在创伤或手术后发生，且可能类似感染。手术干预可导致疾病进展。
病例介绍
本病例系列描述了来自两个大型医疗中心的3例术后坏疽性脓皮病延迟诊断病例。
讨论
结合文献综述，讨论了术后坏疽性脓皮病的流行病学、发病机制、临床和组织病理学表现以及治疗。
结论
术后坏疽性脓皮病（PSPG）可类似包括细菌感染在内的溃疡性疾病。对于细菌培养阴性、尽管使用了广谱抗生素和手术清创仍进展的术后伤口，应怀疑该诊断。认识PSPG的临床特征对于预防严重破坏和畸形至关重要。
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