[良性转移性平滑肌瘤：侵袭性股骨骨肿瘤的罕见病因]
[Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor].
作者信息
Alexandre L, Taillieu F, Arlet J-B, Passeron A, Michon A, Bats A-S, Pouchot J, Ranque B
机构信息
Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.
Service de radiologie, hôpital Européen-Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20 rue Leblanc, 75015 Paris, France.
出版信息
Rev Med Interne. 2018 Jun;39(6):431-434. doi: 10.1016/j.revmed.2018.02.009. Epub 2018 Mar 2.
BACKGROUND
Benign metastasizing leiomyoma (BML) is a rare condition characterized by histologically benign "metastatic" smooth muscle tumors, which can affect women with history of uterine surgery. We report the case of a patient with bone metastases of BML.
CASE REPORT
A 78-year-old woman who had undergone uterine surgery six years before hospital admission, was diagnosed with large pulmonary and pleural metastases that necessitated surgical removal. Pathological examination allowed the diagnosis of BML with positive staining for estrogen and progesterone receptors. Three years later, a BML metastasis in the right femoral diaphysis was unexpectedly discovered and treated by osteosynthesis because of a high risk of fracture. Despite an aromatase-inhibitor treatment, new lungs lesions appeared in the next few months.
CONCLUSION
BML is a potential cause of aggressive, although histologically benign, bone tumor in women with a history of uterine surgery.
背景
良性转移性平滑肌瘤（BML）是一种罕见病症，其特征为组织学上良性的“转移性”平滑肌肿瘤，可影响有子宫手术史的女性。我们报告一例BML骨转移患者的病例。
病例报告
一名78岁女性，入院前六年接受过子宫手术，被诊断为肺部和胸膜有较大转移灶，需要手术切除。病理检查确诊为BML，雌激素和孕激素受体染色呈阳性。三年后，意外发现右股骨干有BML转移灶，因骨折风险高而进行了骨固定治疗。尽管进行了芳香化酶抑制剂治疗，但在接下来的几个月里出现了新的肺部病变。
结论
BML是有子宫手术史女性侵袭性骨肿瘤的潜在病因，尽管其组织学表现为良性。
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